The trans-omics landscape of COVID-19

Peng Wu, Dongsheng Chen, Wencheng Ding, Ping Wu, Hongyan Hou, Yong Bai, Yuwen Zhou, Kezhen Li, Shunian Xiang, Panhong Liu, Jia Ju, Ensong Guo, Jia Liu, Bin Yang, Junpeng Fan, Liang He, Ziyong Sun, Ling Feng, Jian Wang, Tangchun Wu, Hao Wang, Jin Cheng, Hui Xing, Yifan Meng, Yongsheng Li, Yuanliang Zhang, Hongbo Luo, Gang Xie, Xianmei Lan, Ye Tao, Jiafeng Li, Hao Yuan, Kang Huang, Wan Sun, Xiaobo Qian, Zhichao Li, Mingxi Huang, Peiwen Ding, Haoyu Wang, Jiaying Qiu, Feiyue Wang, Shiyou Wang, Jiacheng Zhu, Xiangning Ding, Chaochao Chai, Langchao Liang, Xiaoling Wang, Lihua Luo, Yuzhe Sun, Ying Yang, Zhenkun Zhuang, Tao Li, Lei Tian, Shaoqiao Zhang, Linnan Zhu, Ashley Chang, Lei Chen, Yiquan Wu, Xiaoyan Ma, Fang Chen, Yan Ren, Xun Xu, Siqi Liu, Jian Wang, Huanming Yang, Lin Wang (), Chaoyang Sun (), Ding Ma (), Xin Jin () and Gang Chen ()
Additional contact information
Peng Wu: Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology
Dongsheng Chen: BGI-Shenzhen
Wencheng Ding: Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology
Ping Wu: Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology
Hongyan Hou: Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Yong Bai: BGI-Shenzhen
Yuwen Zhou: BGI-Shenzhen
Kezhen Li: Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology
Shunian Xiang: BGI-Shenzhen
Panhong Liu: BGI-Shenzhen
Jia Ju: BGI-Shenzhen
Ensong Guo: Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology
Jia Liu: Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology
Bin Yang: Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology
Junpeng Fan: Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology
Liang He: Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology
Ziyong Sun: Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Ling Feng: Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology
Jian Wang: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Tangchun Wu: Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology
Hao Wang: Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology
Jin Cheng: Xiangyang Central Hospital, Hubei University of Arts and Science, Xiangyang
Hui Xing: Xiangyang Central Hospital, Hubei University of Arts and Science, Xiangyang
Yifan Meng: State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
Yongsheng Li: Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University
Yuanliang Zhang: BGI-Shenzhen
Hongbo Luo: BGI-Shenzhen
Gang Xie: BGI-Shenzhen
Xianmei Lan: BGI-Shenzhen
Ye Tao: BGI-Shenzhen
Jiafeng Li: BGI-Shenzhen
Hao Yuan: BGI-Shenzhen
Kang Huang: BGI-Shenzhen
Wan Sun: BGI-Shenzhen
Xiaobo Qian: BGI-Shenzhen
Zhichao Li: BGI-Shenzhen
Mingxi Huang: BGI-Shenzhen
Peiwen Ding: BGI-Shenzhen
Haoyu Wang: BGI-Shenzhen
Jiaying Qiu: BGI-Shenzhen
Feiyue Wang: BGI-Shenzhen
Shiyou Wang: BGI-Shenzhen
Jiacheng Zhu: BGI-Shenzhen
Xiangning Ding: BGI-Shenzhen
Chaochao Chai: BGI-Shenzhen
Langchao Liang: BGI-Shenzhen
Xiaoling Wang: BGI-Shenzhen
Lihua Luo: BGI-Shenzhen
Yuzhe Sun: BGI-Shenzhen
Ying Yang: BGI-Shenzhen
Zhenkun Zhuang: BGI-Shenzhen
Tao Li: BGI-Shenzhen
Lei Tian: BGI-Shenzhen
Shaoqiao Zhang: BGI-Hubei, BGI-Shenzhen
Linnan Zhu: BGI-Shenzhen
Ashley Chang: BGI-Shenzhen
Lei Chen: College of Veterinary Medicine, Yangzhou University
Yiquan Wu: HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
Xiaoyan Ma: University of Cambridge
Fang Chen: BGI-Shenzhen
Yan Ren: BGI-Shenzhen
Xun Xu: BGI-Shenzhen
Siqi Liu: BGI-Shenzhen
Jian Wang: BGI-Shenzhen
Huanming Yang: BGI-Shenzhen
Lin Wang: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Chaoyang Sun: Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology
Ding Ma: Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology
Xin Jin: BGI-Shenzhen
Gang Chen: Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology

Nature Communications, 2021, vol. 12, issue 1, 1-16

Abstract: Abstract The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks of COVID-19, especially in those patients without comorbidities, have not been fully investigated. Here we collect blood samples from 231 COVID-19 patients, prefiltered to exclude those with selected comorbidities, yet with symptoms ranging from asymptomatic to critically ill. Using integrative analysis of genomic, transcriptomic, proteomic, metabolomic and lipidomic profiles, we report a trans-omics landscape for COVID-19. Our analyses find neutrophils heterogeneity between asymptomatic and critically ill patients. Meanwhile, neutrophils over-activation, arginine depletion and tryptophan metabolites accumulation correlate with T cell dysfunction in critical patients. Our multi-omics data and characterization of peripheral blood from COVID-19 patients may thus help provide clues regarding pathophysiology of and potential therapeutic strategies for COVID-19.

Date: 2021
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DOI: 10.1038/s41467-021-24482-1

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