Translocation of vaginal microbiota is involved in impairment and protection of uterine health

Jinfeng Wang, Zhanzhan Li, Xiuling Ma, Lifeng Du, Zhen Jia, Xue Cui, Liqun Yu, Jing Yang, Liwen Xiao, Bing Zhang, Huimin Fan and Fangqing Zhao ()
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Jinfeng Wang: Chinese Academy of Sciences
Zhanzhan Li: Chinese Academy of Sciences
Xiuling Ma: Chinese Academy of Sciences
Lifeng Du: Chinese Academy of Sciences
Zhen Jia: Chinese Academy of Sciences
Xue Cui: Aviation General Hospital of China Medical University
Liqun Yu: Aviation General Hospital of China Medical University
Jing Yang: Peking University Third Hospital
Liwen Xiao: Chinese Academy of Sciences
Bing Zhang: Chinese Academy of Sciences
Huimin Fan: Chinese Academy of Sciences
Fangqing Zhao: Chinese Academy of Sciences

Nature Communications, 2021, vol. 12, issue 1, 1-15

Abstract: Abstract The vaginal and uterine microbiota play important roles in the health of the female reproductive system. However, the interactions among the microbes in these two niches and their effects on uterine health remain unclear. Here we profile the vaginal and uterine microbial samples of 145 women, and combine with deep mining of public data and animal experiments to characterize the microbial translocation in the female reproductive tract and its role in modulating uterine health. Synchronous variation and increasing convergence of the uterine and vaginal microbiome with advancing age are shown. We also find that transplanting certain strains of vaginal bacteria into the vagina of rats induces or reduces endometritis-like symptoms, and verify the damaging or protective effects of certain vaginal bacteria on endometrium. This study clarifies the interdependent relationship of vaginal bacterial translocation with uterine microecology and endometrial health, which will undoubtedly increase our understanding of female reproductive health.

Date: 2021
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DOI: 10.1038/s41467-021-24516-8

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