Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth

Todd M. Everson (), Marta Vives-Usano, Emie Seyve, Andres Cardenas, Marina Lacasaña, Jeffrey M. Craig, Corina Lesseur, Emily R. Baker, Nora Fernandez-Jimenez, Barbara Heude, Patrice Perron, Beatriz Gónzalez-Alzaga, Jane Halliday, Maya A. Deyssenroth, Margaret R. Karagas, Carmen Íñiguez, Luigi Bouchard, Pedro Carmona-Sáez, Yuk J. Loke, Ke Hao, Thalia Belmonte, Marie A. Charles, Jordi Martorell-Marugán, Evelyne Muggli, Jia Chen, Mariana F. Fernández, Jorg Tost, Antonio Gómez-Martín, Stephanie J. London, Jordi Sunyer, Carmen J. Marsit, Johanna Lepeule, Marie-France Hivert and Mariona Bustamante ()
Additional contact information
Todd M. Everson: Rollins School of Public Health at Emory University
Marta Vives-Usano: Barcelona Institute of Science and Technology
Emie Seyve: University Grenoble Alpes, Inserm, CNRS, IAB
Andres Cardenas: Harvard Pilgrim Health Care Institute
Marina Lacasaña: CIBER Epidemiología y Salud Pública (CIBERESP)
Jeffrey M. Craig: Murdoch Children’s Research Institute
Corina Lesseur: Icahn School of Medicine at Mount Sinai
Emily R. Baker: Geisel School of Medicine at Dartmouth College
Nora Fernandez-Jimenez: University of the Basque Country (UPV/EHU)
Barbara Heude: Université de Paris, CRESS, INSERM, INRAE
Patrice Perron: University of Sherbrooke
Beatriz Gónzalez-Alzaga: Andalusian School of Public Health
Jane Halliday: University of Melbourne
Maya A. Deyssenroth: Icahn School of Medicine at Mount Sinai
Margaret R. Karagas: Geisel School of Medicine at Dartmouth College
Carmen Íñiguez: CIBER Epidemiología y Salud Pública (CIBERESP)
Luigi Bouchard: University of Sherbrooke
Pedro Carmona-Sáez: GENYO. Centre for Genomics and Oncological Research, Pfizer, University of Granada, Andalusian Regional Government
Yuk J. Loke: Murdoch Children’s Research Institute
Ke Hao: Icahn School of Medicine at Mount Sinai
Thalia Belmonte: IUOPA University of Oviedo
Marie A. Charles: Université de Paris, CRESS, INSERM, INRAE
Jordi Martorell-Marugán: GENYO. Centre for Genomics and Oncological Research, Pfizer, University of Granada, Andalusian Regional Government
Evelyne Muggli: University of Melbourne
Jia Chen: Icahn School of Medicine at Mount Sinai
Mariana F. Fernández: CIBER Epidemiología y Salud Pública (CIBERESP)
Jorg Tost: CEA – Institut de Biologie François Jacob
Antonio Gómez-Martín: GENYO. Centre for Genomics and Oncological Research, Pfizer, University of Granada, Andalusian Regional Government
Stephanie J. London: National Institutes of Health, Department of Health and Human Services
Jordi Sunyer: Universitat Pompeu Fabra
Carmen J. Marsit: Rollins School of Public Health at Emory University
Johanna Lepeule: University Grenoble Alpes, Inserm, CNRS, IAB
Marie-France Hivert: Harvard Pilgrim Health Care Institute
Mariona Bustamante: Barcelona Institute of Science and Technology

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract Maternal smoking during pregnancy (MSDP) contributes to poor birth outcomes, in part through disrupted placental functions, which may be reflected in the placental epigenome. Here we present a meta-analysis of the associations between MSDP and placental DNA methylation (DNAm) and between DNAm and birth outcomes within the Pregnancy And Childhood Epigenetics (PACE) consortium (N = 1700, 344 with MSDP). We identify 443 CpGs that are associated with MSDP, of which 142 associated with birth outcomes, 40 associated with gene expression, and 13 CpGs are associated with all three. Only two CpGs have consistent associations from a prior meta-analysis of cord blood DNAm, demonstrating substantial tissue-specific responses to MSDP. The placental MSDP-associated CpGs are enriched for environmental response genes, growth-factor signaling, and inflammation, which play important roles in placental function. We demonstrate links between placental DNAm, MSDP and poor birth outcomes, which may better inform the mechanisms through which MSDP impacts placental function and fetal growth.

Date: 2021
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-021-24558-y Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24558-y

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-021-24558-y

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().