Immune responses to a single dose of the AZD1222/Covishield vaccine in health care workers

Chandima Jeewandara, Achala Kamaladasa, Pradeep Darshana Pushpakumara, Deshni Jayathilaka, Inoka Sepali Aberathna, Danasekara Rallage Saubhagya Rasikangani Danasekara, Dinuka Guruge, Thushali Ranasinghe, Shashika Dayarathna, Thilagaraj Pathmanathan, Gayasha Somathilake, Panambara Arachchige Deshan Madhusanka, Shyrar Tanussiya Ramu, Tibutius Thanesh Pramanayagam Jayadas, Heshan Kuruppu, Ayesha Wijesinghe, Herath Mudiyanselage Thashmi Nimasha, Dushantha Milroy, Achini Anuja Nandasena, Poththawela Kankanam Gamage Nilanka Sanjeewani, Ruwan Wijayamuni, Sudath Samaraweera, Lisa Schimanski, T. K. Tan, Tao Dong, Graham S. Ogg, Alain Townsend and Gathsaurie Neelika Malavige ()
Additional contact information
Chandima Jeewandara: University of Sri Jayewardenepura
Achala Kamaladasa: University of Sri Jayewardenepura
Pradeep Darshana Pushpakumara: University of Sri Jayewardenepura
Deshni Jayathilaka: University of Sri Jayewardenepura
Inoka Sepali Aberathna: University of Sri Jayewardenepura
Danasekara Rallage Saubhagya Rasikangani Danasekara: University of Sri Jayewardenepura
Dinuka Guruge: Colombo Municipal Council
Thushali Ranasinghe: University of Sri Jayewardenepura
Shashika Dayarathna: University of Sri Jayewardenepura
Thilagaraj Pathmanathan: University of Sri Jayewardenepura
Gayasha Somathilake: University of Sri Jayewardenepura
Panambara Arachchige Deshan Madhusanka: University of Sri Jayewardenepura
Shyrar Tanussiya Ramu: University of Sri Jayewardenepura
Tibutius Thanesh Pramanayagam Jayadas: University of Sri Jayewardenepura
Heshan Kuruppu: University of Sri Jayewardenepura
Ayesha Wijesinghe: University of Sri Jayewardenepura
Herath Mudiyanselage Thashmi Nimasha: University of Sri Jayewardenepura
Dushantha Milroy: Base Hospital
Achini Anuja Nandasena: University of Sri Jayewardenepura
Poththawela Kankanam Gamage Nilanka Sanjeewani: University of Sri Jayewardenepura
Ruwan Wijayamuni: Colombo Municipal Council
Sudath Samaraweera: Ministry of Health Sri Lanka
Lisa Schimanski: University of Oxford
T. K. Tan: University of Oxford
Tao Dong: University of Oxford
Graham S. Ogg: University of Oxford
Alain Townsend: University of Oxford
Gathsaurie Neelika Malavige: University of Sri Jayewardenepura

Nature Communications, 2021, vol. 12, issue 1, 1-9

Abstract: Abstract Several COVID-19 vaccines have received emergency approval. Here we assess the immunogenicity of a single dose of the AZD1222 vaccine, at one month, in a cohort of health care workers (HCWs) (629 naïve and 26 previously infected). 93.4% of naïve HCWs seroconverted, irrespective of age and gender. Haemagglutination test for antibodies to the receptor binding domain (RBD), surrogate neutralization assay (sVNT) and ex vivo IFNγ ELISpot assays were carried out in a sub-cohort. ACE2 blocking antibodies (measured by sVNT) were detected in 67/69 (97.1%) of naïve HCWs. Antibody levels to the RBD of the wild-type virus were higher than to RBD of B.1.1.7, and titres to B.1.351 were very low. Ex vivo T cell responses were observed in 30.8% to 61.7% in naïve HCWs. Previously infected HCWs, developed significantly higher (p

Date: 2021
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DOI: 10.1038/s41467-021-24579-7

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