Combating mosquito-borne diseases using genetic control technologies

Guan-Hong Wang, Stephanie Gamez, Robyn R. Raban, John M. Marshall, Luke Alphey, Ming Li, Jason L. Rasgon and Omar S. Akbari ()
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Guan-Hong Wang: University of California
Stephanie Gamez: University of California
Robyn R. Raban: University of California
John M. Marshall: University of California
Luke Alphey: The Pirbright Institute
Ming Li: University of California
Jason L. Rasgon: The Pennsylvania State University
Omar S. Akbari: University of California

Nature Communications, 2021, vol. 12, issue 1, 1-12

Abstract: Abstract Mosquito-borne diseases, such as dengue and malaria, pose significant global health burdens. Unfortunately, current control methods based on insecticides and environmental maintenance have fallen short of eliminating the disease burden. Scalable, deployable, genetic-based solutions are sought to reduce the transmission risk of these diseases. Pathogen-blocking Wolbachia bacteria, or genome engineering-based mosquito control strategies including gene drives have been developed to address these problems, both requiring the release of modified mosquitoes into the environment. Here, we review the latest developments, notable similarities, and critical distinctions between these promising technologies and discuss their future applications for mosquito-borne disease control.

Date: 2021
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DOI: 10.1038/s41467-021-24654-z

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