Self-healing polyurethane-elastomer with mechanical tunability for multiple biomedical applications in vivo

Chenyu Jiang, Luzhi Zhang, Qi Yang, Shixing Huang, Hongpeng Shi, Qiang Long, Bei Qian, Zenghe Liu, Qingbao Guan, Mingjian Liu, Renhao Yang, Qiang Zhao (), Zhengwei You () and Xiaofeng Ye ()
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Chenyu Jiang: Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine
Luzhi Zhang: Donghua University
Qi Yang: Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine
Shixing Huang: Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine
Hongpeng Shi: Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine
Qiang Long: Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine
Bei Qian: Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine
Zenghe Liu: Donghua University
Qingbao Guan: Donghua University
Mingjian Liu: Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine
Renhao Yang: Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine
Qiang Zhao: Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine
Zhengwei You: Donghua University
Xiaofeng Ye: Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract The unique properties of self-healing materials hold great potential in the field of biomedical engineering. Although previous studies have focused on the design and synthesis of self-healing materials, their application in in vivo settings remains limited. Here, we design a series of biodegradable and biocompatible self-healing elastomers (SHEs) with tunable mechanical properties, and apply them to various disease models in vivo, in order to test their reparative potential in multiple tissues and at physiological conditions. We validate the effectiveness of SHEs as promising therapies for aortic aneurysm, nerve coaptation and bone immobilization in three animal models. The data presented here support the translation potential of SHEs in diverse settings, and pave the way for the development of self-healing materials in clinical contexts.

Date: 2021
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DOI: 10.1038/s41467-021-24680-x

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