Development of a quantitative prediction algorithm for target organ-specific similarity of human pluripotent stem cell-derived organoids and cells

Mi-Ok Lee, Su-gi Lee, Cho-Rok Jung, Ye Seul Son, Jae-Woon Ryu, Kwang Bo Jung, Jun-Ho Ahn, Jung-Hwa Oh, Hyang-Ae Lee, Jung Hwa Lim, Janghwan Kim, Insu Jang, Jinhyuk Choi, Jaeeun Jung, Kunhyang Park, Byungwook Lee, Dae-Soo Kim (), Mi-Young Son () and Hyun-Soo Cho ()
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Mi-Ok Lee: Korea Research Institute of Bioscience and Biotechnology
Su-gi Lee: Korea Research Institute of Bioscience and Biotechnology
Cho-Rok Jung: Korea Research Institute of Bioscience and Biotechnology
Ye Seul Son: Korea Research Institute of Bioscience and Biotechnology
Jae-Woon Ryu: Korea Research Institute of Bioscience and Biotechnology
Kwang Bo Jung: Korea Research Institute of Bioscience and Biotechnology
Jun-Ho Ahn: Korea Institute of Toxicology (KIT)
Jung-Hwa Oh: Korea Institute of Toxicology (KIT)
Hyang-Ae Lee: Korea Institute of Toxicology (KIT)
Jung Hwa Lim: Korea Research Institute of Bioscience and Biotechnology
Janghwan Kim: Korea Research Institute of Bioscience and Biotechnology
Insu Jang: Korea Research Institute of Bioscience and Biotechnology
Jinhyuk Choi: Korea Research Institute of Bioscience and Biotechnology
Jaeeun Jung: Korea Research Institute of Bioscience and Biotechnology
Kunhyang Park: Korea Research Institute of Bioscience and Biotechnology
Byungwook Lee: Korea Research Institute of Bioscience and Biotechnology
Dae-Soo Kim: Korea Research Institute of Bioscience and Biotechnology
Mi-Young Son: Korea Research Institute of Bioscience and Biotechnology
Hyun-Soo Cho: Korea Research Institute of Bioscience and Biotechnology

Nature Communications, 2021, vol. 12, issue 1, 1-14

Abstract: Abstract Human pluripotent stem cell (hPSC)-derived organoids and cells have similar characteristics to human organs and tissues. Thus, in vitro human organoids and cells serve as a superior alternative to conventional cell lines and animal models in drug development and regenerative medicine. For a simple and reproducible analysis of the quality of organoids and cells to compensate for the shortcomings of existing experimental validation studies, a quantitative evaluation method should be developed. Here, using the GTEx database, we construct a quantitative calculation system to assess similarity to the human organs. To evaluate our system, we generate hPSC-derived organoids and cells, and detected organ similarity. To facilitate the access of our system by researchers, we develop a web-based user interface presenting similarity to the appropriate organs as percentages. Thus, this program could provide valuable information for the generation of high-quality organoids and cells and a strategy to guide proper lineage-oriented differentiation.

Date: 2021
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DOI: 10.1038/s41467-021-24746-w

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