A connexin/ifi30 pathway bridges HSCs with their niche to dampen oxidative stress

Pietro Cacialli, Christopher B. Mahony, Tim Petzold, Patrizia Bordignon, Anne-Laure Rougemont and Julien Y. Bertrand ()
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Pietro Cacialli: University of Geneva, Faculty of Medicine, Department of Pathology and Immunology
Christopher B. Mahony: University of Geneva, Faculty of Medicine, Department of Pathology and Immunology
Tim Petzold: University of Geneva, Faculty of Medicine, Department of Pathology and Immunology
Patrizia Bordignon: Division of clinical pathology, Geneva University Hospitals
Anne-Laure Rougemont: Division of clinical pathology, Geneva University Hospitals
Julien Y. Bertrand: University of Geneva, Faculty of Medicine, Department of Pathology and Immunology

Nature Communications, 2021, vol. 12, issue 1, 1-15

Abstract: Abstract Reactive oxygen species (ROS) represent a by-product of metabolism and their excess is toxic for hematopoietic stem and progenitor cells (HSPCs). During embryogenesis, a small number of HSPCs are produced from the hemogenic endothelium, before they colonize a transient organ where they expand, for example the fetal liver in mammals. In this study, we use zebrafish to understand the molecular mechanisms that are important in the caudal hematopoietic tissue (equivalent to the mammalian fetal liver) to promote HSPC expansion. High levels of ROS are deleterious for HSPCs in this niche, however this is rescued by addition of antioxidants. We show that Cx41.8 is important to lower ROS levels in HSPCs. We also demonstrate a new role for ifi30, known to be involved in the immune response. In the hematopoietic niche, Ifi30 can recycle oxidized glutathione to allow HSPCs to dampen their levels of ROS, a role that could be conserved in human fetal liver.

Date: 2021
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DOI: 10.1038/s41467-021-24831-0

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