Imparting multi-functionality to covalent organic framework nanoparticles by the dual-ligand assistant encapsulation strategy

Liang Chen, Wenxing Wang, Jia Tian, Fanxing Bu, Tiancong Zhao, Minchao Liu, Runfeng Lin, Fan Zhang, Myongsoo Lee, Dongyuan Zhao and Xiaomin Li ()
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Liang Chen: Fudan University
Wenxing Wang: Fudan University
Jia Tian: University of Victoria
Fanxing Bu: Fudan University
Tiancong Zhao: Fudan University
Minchao Liu: Fudan University
Runfeng Lin: Fudan University
Fan Zhang: Fudan University
Myongsoo Lee: Fudan University
Dongyuan Zhao: Fudan University
Xiaomin Li: Fudan University

Nature Communications, 2021, vol. 12, issue 1, 1-10

Abstract: Abstract The potential applications of covalent organic frameworks (COFs) can be further developed by encapsulating functional nanoparticles within the frameworks. However, the synthesis of monodispersed core@shell structured COF nanocomposites without agglomeration remains a significant challenge. Herein, we present a versatile dual-ligand assistant strategy for interfacial growth of COFs on the functional nanoparticles with abundant physicochemical properties. Regardless of the composition, geometry or surface properties of the core, the obtained core@shell structured nanocomposites with controllable shell-thickness are very uniform without agglomeration. The derived bowl-shape, yolk@shell, core@satellites@shell nanostructures can also be fabricated delicately. As a promising type of photosensitizer for photodynamic therapy (PDT), the porphyrin-based COFs were grown onto upconversion nanoparticles (UCNPs). With the assistance of the near-infrared (NIR) to visible optical property of UCNPs core and the intrinsic porosity of COF shell, the core@shell nanocomposites can be applied as a nanoplatform for NIR-activated PDT with deep tissue penetration and chemotherapeutic drug delivery.

Date: 2021
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DOI: 10.1038/s41467-021-24838-7

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