Endogenous control of inflammation characterizes pregnant women with asymptomatic or paucisymptomatic SARS-CoV-2 infection

Sara De Biasi, Domenico Lo Tartaro, Lara Gibellini, Annamaria Paolini, Andrew Quong, Carlene Petes, Geneve Awong, Samuel Douglas, Dongxia Lin, Jordan Nieto, Francesco Maria Galassi, Rebecca Borella, Lucia Fidanza, Marco Mattioli, Chiara Leone, Isabella Neri, Marianna Meschiari, Luca Cicchetti, Anna Iannone, Tommaso Trenti, Mario Sarti, Massimo Girardis, Giovanni Guaraldi, Cristina Mussini, Fabio Facchinetti and Andrea Cossarizza ()
Additional contact information
Sara De Biasi: University of Modena and Reggio Emilia School of Medicine
Domenico Lo Tartaro: University of Modena and Reggio Emilia School of Medicine
Lara Gibellini: University of Modena and Reggio Emilia School of Medicine
Annamaria Paolini: University of Modena and Reggio Emilia School of Medicine
Andrew Quong: Fluidigm Corporation
Carlene Petes: Fluidigm Corporation
Geneve Awong: Fluidigm Corporation
Samuel Douglas: Fluidigm Corporation
Dongxia Lin: Fluidigm Corporation
Jordan Nieto: Fluidigm Corporation
Francesco Maria Galassi: Flinders University
Rebecca Borella: University of Modena and Reggio Emilia School of Medicine
Lucia Fidanza: University of Modena and Reggio Emilia School of Medicine
Marco Mattioli: University of Modena and Reggio Emilia School of Medicine
Chiara Leone: University of Modena and Reggio Emilia School of Medicine
Isabella Neri: University of Modena and Reggio Emilia School of Medicine
Marianna Meschiari: AOU Policlinico and University of Modena and Reggio Emilia
Luca Cicchetti: Labospace
Anna Iannone: University of Modena and Reggio Emilia School of Medicine
Tommaso Trenti: AOU Policlinico
Mario Sarti: AOU Policlinico
Massimo Girardis: AOU Policlinico and University of Modena and Reggio Emilia
Giovanni Guaraldi: AOU Policlinico and University of Modena and Reggio Emilia
Cristina Mussini: AOU Policlinico and University of Modena and Reggio Emilia
Fabio Facchinetti: University of Modena and Reggio Emilia School of Medicine
Andrea Cossarizza: University of Modena and Reggio Emilia School of Medicine

Nature Communications, 2021, vol. 12, issue 1, 1-16

Abstract: Abstract SARS-CoV-2 infection can affect all human beings, including pregnant women. Thus, understanding the immunological changes induced by the virus during pregnancy is nowadays of pivotal importance. Here, using peripheral blood from 14 pregnant women with asymptomatic or mild SARS-CoV-2 infection, we investigate cell proliferation and cytokine production, measure plasma levels of 62 cytokines, and perform a 38-parameter mass cytometry analysis. Our results show an increase in low density neutrophils but no lymphopenia or gross alterations of white blood cells, which display normal levels of differentiation, activation or exhaustion markers and show well preserved functionality. Meanwhile, the plasma levels of anti-inflammatory cytokines such as interleukin (IL)-1RA, IL-10 and IL-19 are increased, those of IL-17, PD-L1 and D-dimer are decreased, but IL-6 and other inflammatory molecules remain unchanged. Our profiling of antiviral immune responses may thus help develop therapeutic strategies to avoid virus-induced damages during pregnancy.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24940-w

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DOI: 10.1038/s41467-021-24940-w

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