Dendrimer end-terminal motif-dependent evasion of human complement and complement activation through IgM hitchhiking

Lin-Ping Wu, Mario Ficker, Jørn B. Christensen, Dmitri Simberg, Panagiotis N. Trohopoulos and Seyed M. Moghimi ()
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Lin-Ping Wu: University of Copenhagen
Mario Ficker: University of Copenhagen
Jørn B. Christensen: University of Copenhagen
Dmitri Simberg: University of Colorado Anschutz Medical Campus
Panagiotis N. Trohopoulos: CosmoPHOS Ltd
Seyed M. Moghimi: University of Copenhagen

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract Complement is an enzymatic humoral pattern-recognition defence system of the body. Non-specific deposition of blood biomolecules on nanomedicines triggers complement activation through the alternative pathway, but complement-triggering mechanisms of nanomaterials with dimensions comparable to or smaller than many globular blood proteins are unknown. Here we study this using a library of

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24960-6

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DOI: 10.1038/s41467-021-24960-6

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