Arsenene-mediated multiple independently targeted reactive oxygen species burst for cancer therapy

Na Kong, Hanjie Zhang, Chan Feng, Chuang Liu, Yufen Xiao, Xingcai Zhang, Lin Mei, Jong Seung Kim, Wei Tao () and Xiaoyuan Ji ()
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Na Kong: Harvard Medical School
Hanjie Zhang: Tianjin University
Chan Feng: Harvard Medical School
Chuang Liu: Harvard Medical School
Yufen Xiao: Harvard Medical School
Xingcai Zhang: Harvard University
Lin Mei: Chinese Academy of Medical Sciences and Peking Union Medical College
Jong Seung Kim: Korea University
Wei Tao: Harvard Medical School
Xiaoyuan Ji: Harvard Medical School

Nature Communications, 2021, vol. 12, issue 1, 1-18

Abstract: Abstract The modulation of intracellular reactive oxygen species (ROS) levels is crucial for cellular homeostasis and determination of cellular fate. A sublethal level of ROS sustains cell proliferation, differentiation and promotes tumor metastasis, while a drastic ROS burst directly induces apoptosis. Herein, surface-oxidized arsenene nanosheets (As/AsxOy NSs) with type II heterojunction are fabricated with efficient ·O2− and 1O2 production and glutathione consumption through prolonging the lifetime of photo-excited electron-hole pairs. Moreover, the portion of AsxOy with oxygen vacancies not only catalyzes a Fenton-like reaction, generating ·OH and O2 from H2O2, but also inactivates main anti-oxidants to cut off the “retreat routes” of ROS. After polydopamine (PDA) and cancer cell membrane (M) coating, the engineered As/AsxOy@PDA@M NSs serve as an intelligent theranostic platform with active tumor targeting and long-term blood circulation. Given its narrow-band-gap-enabled in vivo fluorescence imaging properties, As/AsxOy@PDA@M NSs could be applied as an imaging-guided non-invasive and real-time nanomedicine for cancer therapy.

Date: 2021
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DOI: 10.1038/s41467-021-24961-5

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