Evolutionary dynamics of multidrug resistant Salmonella enterica serovar 4,[5],12:i:- in Australia

Danielle J. Ingle (), Rebecca L. Ambrose, Sarah L. Baines, Sebastian Duchene, Anders Gonçalves da Silva, Darren Y. J. Lee, Miriam Jones, Mary Valcanis, George Taiaroa, Susan A. Ballard, Martyn D. Kirk, Benjamin P. Howden, Jaclyn S. Pearson and Deborah A. Williamson ()
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Danielle J. Ingle: Australian National University
Rebecca L. Ambrose: Hudson Institute of Medical Research
Sarah L. Baines: The University of Melbourne at The Peter Doherty Institute for Infection and Immunity
Sebastian Duchene: The University of Melbourne at The Peter Doherty Institute for Infection and Immunity
Anders Gonçalves da Silva: The University of Melbourne at The Peter Doherty Institute for Infection and Immunity
Darren Y. J. Lee: The University of Melbourne at The Peter Doherty Institute for Infection and Immunity
Miriam Jones: Hudson Institute of Medical Research
Mary Valcanis: The University of Melbourne at The Peter Doherty Institute for Infection and Immunity
George Taiaroa: The University of Melbourne at The Peter Doherty Institute for Infection and Immunity
Susan A. Ballard: The University of Melbourne at The Peter Doherty Institute for Infection and Immunity
Martyn D. Kirk: Australian National University
Benjamin P. Howden: The University of Melbourne at The Peter Doherty Institute for Infection and Immunity
Jaclyn S. Pearson: Hudson Institute of Medical Research
Deborah A. Williamson: The University of Melbourne at The Peter Doherty Institute for Infection and Immunity

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract Salmonella enterica serovar 4,[5],12:i:- (Salmonella 4,[5],12:i:-) is a monophasic variant of Salmonella Typhimurium that has emerged as a global cause of multidrug resistant salmonellosis. We used Bayesian phylodynamics, genomic epidemiology, and phenotypic characterization to describe the emergence and evolution of Salmonella 4,[5],12:i:- in Australia. We show that the interruption of the genetic region surrounding the phase II flagellin, FljB, causing a monophasic phenotype, represents a stepwise evolutionary event through the accumulation of mobile resistance elements with minimal impairment to bacterial fitness. We identify three lineages with different population dynamics and discrete antimicrobial resistance profiles emerged, likely reflecting differential antimicrobial selection pressures. Two lineages are associated with travel to South-East Asia and the third lineage is endemic to Australia. Moreover antimicrobial-resistant Salmonella 4,[5],12:i- lineages efficiently infected and survived in host phagocytes and epithelial cells without eliciting significant cellular cytotoxicity, suggesting a suppression of host immune response that may facilitate the persistence of Salmonella 4,[5],12:i:-.

Date: 2021
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DOI: 10.1038/s41467-021-25073-w

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