Conversion of dietary inositol into propionate and acetate by commensal Anaerostipes associates with host health

Thi Phuong Nam Bui (), Louise Mannerås-Holm, Robert Puschmann, Hao Wu, Antonio Dario Troise, Bart Nijsse, Sjef Boeren, Fredrik Bäckhed, Dorothea Fiedler and Willem M. deVos ()
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Thi Phuong Nam Bui: Wageningen University
Louise Mannerås-Holm: University of Gothenburg
Robert Puschmann: Leibniz-Forschungsinstitut für Molekulare Pharmakologie
Hao Wu: University of Gothenburg
Antonio Dario Troise: Proteomics & Mass Spectrometry Laboratory, ISPAAM, National Research Council
Bart Nijsse: Wageningen University
Sjef Boeren: Wageningen University
Fredrik Bäckhed: University of Gothenburg
Dorothea Fiedler: Leibniz-Forschungsinstitut für Molekulare Pharmakologie
Willem M. deVos: Wageningen University

Nature Communications, 2021, vol. 12, issue 1, 1-16

Abstract: Abstract We describe the anaerobic conversion of inositol stereoisomers to propionate and acetate by the abundant intestinal genus Anaerostipes. A inositol pathway was elucidated by nuclear magnetic resonance using [13C]-inositols, mass spectrometry and proteogenomic analyses in A. rhamnosivorans, identifying 3-oxoacid CoA transferase as a key enzyme involved in both 3-oxopropionyl-CoA and propionate formation. This pathway also allowed conversion of phytate-derived inositol into propionate as shown with [13C]-phytate in fecal samples amended with A. rhamnosivorans. Metabolic and (meta)genomic analyses explained the adaptation of Anaerostipes spp. to inositol-containing substrates and identified a propionate-production gene cluster to be inversely associated with metabolic biomarkers in (pre)diabetes cohorts. Co-administration of myo-inositol with live A. rhamnosivorans in western-diet fed mice reduced fasting-glucose levels comparing to heat-killed A. rhamnosivorans after 6-weeks treatment. Altogether, these data suggest a potential beneficial role for intestinal Anaerostipes spp. in promoting host health.

Date: 2021
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DOI: 10.1038/s41467-021-25081-w

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