Multifaceted mechanisms mediating cystine starvation-induced ferroptosis

Zhennan Shi, Nathchar Naowarojna, Zijian Pan and Yilong Zou ()
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Zhennan Shi: Westlake Four-Dimensional Dynamic Metabolomics (Meta4D) Lab, Westlake Laboratory of Life Sciences and Biomedicine
Nathchar Naowarojna: Westlake Four-Dimensional Dynamic Metabolomics (Meta4D) Lab, Westlake Laboratory of Life Sciences and Biomedicine
Zijian Pan: Westlake University
Yilong Zou: Westlake Four-Dimensional Dynamic Metabolomics (Meta4D) Lab, Westlake Laboratory of Life Sciences and Biomedicine

Nature Communications, 2021, vol. 12, issue 1, 1-4

Abstract: The cyst(e)ine/glutathione (GSH)/glutathione peroxidase 4 (GPX4) axis is the most frequently targeted pathway to trigger the ferroptosis cascade and suppress tumor growth. Two recent studies present additional mechanisms underlying cystine starvation-induced ferroptosis apart from impaired GSH synthesis.

Date: 2021
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DOI: 10.1038/s41467-021-25159-5

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