Rational design of pyrrole derivatives with aggregation-induced phosphorescence characteristics for time-resolved and two-photon luminescence imaging

Jianhui Yang, Yahui Zhang, Xinghui Wu, Wenbo Dai, Dan Chen, Jianbing Shi, Bin Tong, Qian Peng, Haiyan Xie, Zhengxu Cai (), Yuping Dong and Xin Zhang ()
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Jianhui Yang: Beijing Institute of Technology
Yahui Zhang: School of Life Science, Advanced Research Institute of Multidisciplinary Science, Beijing Institute of Technology
Xinghui Wu: Beijing Institute of Technology
Wenbo Dai: Beijing Institute of Technology
Dan Chen: Cancer Hospital of China Medical University, Liaoning Cancer Hospital
Jianbing Shi: Beijing Institute of Technology
Bin Tong: Beijing Institute of Technology
Qian Peng: University of Chinese Academy of Sciences
Haiyan Xie: School of Life Science, Advanced Research Institute of Multidisciplinary Science, Beijing Institute of Technology
Zhengxu Cai: Beijing Institute of Technology
Yuping Dong: Beijing Institute of Technology
Xin Zhang: Cancer Hospital of China Medical University, Liaoning Cancer Hospital

Nature Communications, 2021, vol. 12, issue 1, 1-8

Abstract: Abstract Pure organic room-temperature phosphorescent (RTP) materials have been suggested to be promising bioimaging materials due to their good biocompatibility and long emission lifetime. Herein, we report a class of RTP materials. These materials are developed through the simple introduction of an aromatic carbonyl to a tetraphenylpyrrole molecule and also exhibit aggregation-induced emission (AIE) properties. These molecules show non-emission in solution and purely phosphorescent emission in the aggregated state, which are desirable properties for biological imaging. Highly crystalline nanoparticles can be easily fabricated with a long emission lifetime (20 μs), which eliminate background fluorescence interference from cells and tissues. The prepared nanoparticles demonstrate two-photon absorption characteristics and can be excited by near infrared (NIR) light, making them promising materials for deep-tissue optical imaging. This integrated aggregation-induced phosphorescence (AIP) strategy diversifies the existing pool of bioimaging agents to inspire the development of bioprobes in the future.

Date: 2021
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DOI: 10.1038/s41467-021-25174-6

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