PERM1 interacts with the MICOS-MIB complex to connect the mitochondria and sarcolemma via ankyrin B

Theresa Bock, Clara Türk, Sriram Aravamudhan, Lena Keufgens, Wilhelm Bloch, Dieu Hien Rozsivalova, Vanina Romanello, Leonardo Nogara, Bert Blaauw, Aleksandra Trifunovic, Thomas Braun and Marcus Krüger ()
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Theresa Bock: Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD)
Clara Türk: BASF SE, Metabolomics and Proteomics
Sriram Aravamudhan: Cell Signaling Technology
Lena Keufgens: Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD)
Wilhelm Bloch: German Sport University Cologne
Dieu Hien Rozsivalova: Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD)
Vanina Romanello: University of Padova
Leonardo Nogara: University of Padova
Bert Blaauw: University of Padova
Aleksandra Trifunovic: Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD)
Thomas Braun: Max Planck Institute for Heart and Lung Research
Marcus Krüger: Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD)

Nature Communications, 2021, vol. 12, issue 1, 1-15

Abstract: Abstract Skeletal muscle subsarcolemmal mitochondria (SSM) and intermyofibrillar mitochondria subpopulations have distinct metabolic activity and sensitivity, though the mechanisms that localize SSM to peripheral areas of muscle fibers are poorly understood. A protein interaction study and complexome profiling identifies PERM1 interacts with the MICOS-MIB complex. Ablation of Perm1 in mice reduces muscle force, decreases mitochondrial membrane potential and complex I activity, and reduces the numbers of SSM in skeletal muscle. We demonstrate PERM1 interacts with the intracellular adaptor protein ankyrin B (ANKB) that connects the cytoskeleton to the plasma membrane. Moreover, we identify a C-terminal transmembrane helix that anchors PERM1 into the outer mitochondrial membrane. We conclude PERM1 functions in the MICOS-MIB complex and acts as an adapter to connect the mitochondria with the sarcolemma via ANKB.

Date: 2021
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DOI: 10.1038/s41467-021-25185-3

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