The cytokines HGF and CXCL13 predict the severity and the mortality in COVID-19 patients

Matthieu Perreau, Madeleine Suffiotti, Pedro Marques-Vidal, Aurelie Wiedemann, Yves Levy, Cédric Laouénan, Jade Ghosn, Craig Fenwick, Denis Comte, Thierry Roger, Jean Regina, Peter Vollenweider, Gerard Waeber, Mauro Oddo, Thierry Calandra and Giuseppe Pantaleo ()
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Matthieu Perreau: Lausanne University Hospital, University of Lausanne
Madeleine Suffiotti: Lausanne University Hospital, University of Lausanne
Pedro Marques-Vidal: Lausanne University Hospital, University of Lausanne
Aurelie Wiedemann: Université Paris-Est, Faculté de Médecine, INSERM U955
Yves Levy: Université Paris-Est, Faculté de Médecine, INSERM U955
Cédric Laouénan: AP-HP, Hôpital Bichat, Département Épidémiologie Biostatistiques et Recherche Clinique, INSERM, Centre d’Investigation clinique-Epidémiologie Clinique 1425
Jade Ghosn: AP-HP, Hôpital Bichat, Service de Maladies Infectieuses et Tropicales
Craig Fenwick: Lausanne University Hospital, University of Lausanne
Denis Comte: Lausanne University Hospital, University of Lausanne
Thierry Roger: Lausanne University Hospital, University of Lausanne
Jean Regina: Lausanne University Hospital, University of Lausanne
Peter Vollenweider: Lausanne University Hospital, University of Lausanne
Gerard Waeber: Lausanne University Hospital, University of Lausanne
Mauro Oddo: Lausanne University Hospital, University of Lausanne
Thierry Calandra: Lausanne University Hospital, University of Lausanne
Giuseppe Pantaleo: Lausanne University Hospital, University of Lausanne

Nature Communications, 2021, vol. 12, issue 1, 1-10

Abstract: Abstract The objective of the present study was to identify biological signatures of severe coronavirus disease 2019 (COVID-19) predictive of admission in the intensive care unit (ICU). Over 170 immunological markers were investigated in a ‘discovery’ cohort (n = 98 patients) of the Lausanne University Hospital (LUH-1). Here we report that 13 out of 49 cytokines were significantly associated with ICU admission in the three cohorts (P

Date: 2021
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DOI: 10.1038/s41467-021-25191-5

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