Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice

Eunee Lee, Seungjoon Lee, Jae Jin Shin, Woochul Choi, Changuk Chung, Suho Lee, Jihye Kim, Seungmin Ha, Ryunhee Kim, Taesun Yoo, Ye-Eun Yoo, Jisoo Kim, Young Woo Noh, Issac Rhim, Soo Yeon Lee, Woohyun Kim, Taekyung Lee, Hyogeun Shin, Il-Joo Cho, Karl Deisseroth, Sang Jeong Kim, Joo Min Park (), Min Whan Jung (), Se-Bum Paik () and Eunjoon Kim ()
Additional contact information
Eunee Lee: Institute for Basic Science (IBS)
Seungjoon Lee: Department of Biological Sciences, KAIST
Jae Jin Shin: Seoul National University
Woochul Choi: Korea Advanced Institute for Science and Technology (KAIST)
Changuk Chung: Institute for Basic Science (IBS)
Suho Lee: Department of Biological Sciences, KAIST
Jihye Kim: Institute for Basic Science (IBS)
Seungmin Ha: Institute for Basic Science (IBS)
Ryunhee Kim: Institute for Basic Science (IBS)
Taesun Yoo: Institute for Basic Science (IBS)
Ye-Eun Yoo: Department of Biological Sciences, KAIST
Jisoo Kim: Department of Biological Sciences, KAIST
Young Woo Noh: Department of Biological Sciences, KAIST
Issac Rhim: Institute for Basic Science (IBS)
Soo Yeon Lee: Department of Biological Sciences, KAIST
Woohyun Kim: Department of Biological Sciences, KAIST
Taekyung Lee: Institute for Basic Science (IBS)
Hyogeun Shin: Korea Institute of Science and Technology (KIST)
Il-Joo Cho: Korea Institute of Science and Technology (KIST)
Karl Deisseroth: Stanford University
Sang Jeong Kim: Seoul National University
Joo Min Park: Institute for Basic Science (IBS)
Min Whan Jung: Institute for Basic Science (IBS)
Se-Bum Paik: Korea Advanced Institute for Science and Technology (KAIST)
Eunjoon Kim: Institute for Basic Science (IBS)

Nature Communications, 2021, vol. 12, issue 1, 1-20

Abstract: Abstract NMDA receptor (NMDAR) and GABA neuronal dysfunctions are observed in animal models of autism spectrum disorders, but how these dysfunctions impair social cognition and behavior remains unclear. We report here that NMDARs in cortical parvalbumin (Pv)-positive interneurons cooperate with gap junctions to promote high-frequency (>80 Hz) Pv neuronal burst firing and social cognition. Shank2–/– mice, displaying improved sociability upon NMDAR activation, show impaired cortical social representation and inhibitory neuronal burst firing. Cortical Shank2–/– Pv neurons show decreased NMDAR activity, which suppresses the cooperation between NMDARs and gap junctions (GJs) for normal burst firing. Shank2–/– Pv neurons show compensatory increases in GJ activity that are not sufficient for social rescue. However, optogenetic boosting of Pv neuronal bursts, requiring GJs, rescues cortical social cognition in Shank2–/– mice, similar to the NMDAR-dependent social rescue. Therefore, NMDARs and gap junctions cooperate to promote cortical Pv neuronal bursts and social cognition.

Date: 2021
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-021-25356-2 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25356-2

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-021-25356-2

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().