Point-of-care antimicrobial coating protects orthopaedic implants from bacterial challenge

Weixian Xi, Vishal Hegde, Stephen D. Zoller, Howard Y. Park, Christopher M. Hart, Takeru Kondo, Christopher D. Hamad, Yan Hu, Amanda H. Loftin, Daniel O. Johansen, Zachary Burke, Samuel Clarkson, Chad Ishmael, Kellyn Hori, Zeinab Mamouei, Hiroko Okawa, Ichiro Nishimura, Nicholas M. Bernthal () and Tatiana Segura ()
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Weixian Xi: University of California Los Angeles
Vishal Hegde: David Geffen School of Medicine at University of California Los Angeles
Stephen D. Zoller: David Geffen School of Medicine at University of California Los Angeles
Howard Y. Park: David Geffen School of Medicine at University of California Los Angeles
Christopher M. Hart: David Geffen School of Medicine at University of California Los Angeles
Takeru Kondo: University of California Los Angeles School of Dentistry
Christopher D. Hamad: David Geffen School of Medicine at University of California Los Angeles
Yan Hu: David Geffen School of Medicine at University of California Los Angeles
Amanda H. Loftin: David Geffen School of Medicine at University of California Los Angeles
Daniel O. Johansen: David Geffen School of Medicine at University of California Los Angeles
Zachary Burke: David Geffen School of Medicine at University of California Los Angeles
Samuel Clarkson: David Geffen School of Medicine at University of California Los Angeles
Chad Ishmael: David Geffen School of Medicine at University of California Los Angeles
Kellyn Hori: David Geffen School of Medicine at University of California Los Angeles
Zeinab Mamouei: David Geffen School of Medicine at University of California Los Angeles
Hiroko Okawa: University of California Los Angeles School of Dentistry
Ichiro Nishimura: University of California Los Angeles School of Dentistry
Nicholas M. Bernthal: David Geffen School of Medicine at University of California Los Angeles
Tatiana Segura: University of California Los Angeles

Nature Communications, 2021, vol. 12, issue 1, 1-15

Abstract: Abstract Implant related infections are the most common cause of joint arthroplasty failure, requiring revision surgeries and a new implant, resulting in a cost of $8.6 billion annually. To address this problem, we created a class of coating technology that is applied in the operating room, in a procedure that takes less than 10 min, and can incorporate any desired antibiotic. Our coating technology uses an in situ coupling reaction of branched poly(ethylene glycol) and poly(allyl mercaptan) (PEG-PAM) polymers to generate an amphiphilic polymeric coating. We show in vivo efficacy in preventing implant infection in both post-arthroplasty infection and post-spinal surgery infection mouse models. Our technology displays efficacy with or without systemic antibiotics, the standard of care. Our coating technology is applied in a clinically relevant time frame, does not require modification of implant manufacturing process, and does not change the implant shelf life.

Date: 2021
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DOI: 10.1038/s41467-021-25383-z

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