Implantable optical fibers for immunotherapeutics delivery and tumor impedance measurement

Ai Lin Chin, Shan Jiang, Eungyo Jang, Liqian Niu, Liwu Li, Xiaoting Jia () and Rong Tong ()
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Ai Lin Chin: Virginia Polytechnic Institute and State University
Shan Jiang: Virginia Polytechnic Institute and State University
Eungyo Jang: Virginia Polytechnic Institute and State University
Liqian Niu: Virginia Polytechnic Institute and State University
Liwu Li: Virginia Polytechnic Institute and State University
Xiaoting Jia: Virginia Polytechnic Institute and State University
Rong Tong: Virginia Polytechnic Institute and State University

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract Immune checkpoint blockade antibodies have promising clinical applications but suffer from disadvantages such as severe toxicities and moderate patient–response rates. None of the current delivery strategies, including local administration aiming to avoid systemic toxicities, can sustainably supply drugs over the course of weeks; adjustment of drug dose, either to lower systemic toxicities or to augment therapeutic response, is not possible. Herein, we develop an implantable miniaturized device using electrode-embedded optical fibers with both local delivery and measurement capabilities over the course of a few weeks. The combination of local immune checkpoint blockade antibodies delivery via this device with photodynamic therapy elicits a sustained anti-tumor immunity in multiple tumor models. Our device uses tumor impedance measurement for timely presentation of treatment outcomes, and allows modifications to the delivered drugs and their concentrations, rendering this device potentially useful for on-demand delivery of potent immunotherapeutics without exacerbating toxicities.

Date: 2021
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DOI: 10.1038/s41467-021-25391-z

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