Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice

Elina Akalestou, Kinga Suba, Livia Lopez-Noriega, Eleni Georgiadou, Pauline Chabosseau, Alasdair Gallie, Asger Wretlind, Cristina Legido-Quigley, Isabelle Leclerc, Victoria Salem () and Guy A. Rutter ()
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Elina Akalestou: Hammersmith Hospital Campus
Kinga Suba: Hammersmith Hospital Campus
Livia Lopez-Noriega: Hammersmith Hospital Campus
Eleni Georgiadou: Hammersmith Hospital Campus
Pauline Chabosseau: Hammersmith Hospital Campus
Alasdair Gallie: Central Biological Services (CBS) Hammersmith Hospital Campus
Asger Wretlind: Steno Diabetes Center, Gentofte
Cristina Legido-Quigley: Steno Diabetes Center, Gentofte
Isabelle Leclerc: Hammersmith Hospital Campus
Victoria Salem: Hammersmith Hospital Campus
Guy A. Rutter: Hammersmith Hospital Campus

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract Bariatric surgery improves both insulin sensitivity and secretion and can induce diabetes remission. However, the mechanisms and time courses of these changes, particularly the impact on β cell function, are difficult to monitor directly. In this study, we investigated the effect of Vertical Sleeve Gastrectomy (VSG) on β cell function in vivo by imaging Ca2+ dynamics in islets engrafted into the anterior eye chamber. Mirroring its clinical utility, VSG in mice results in significantly improved glucose tolerance, and enhanced insulin secretion. We reveal that these benefits are underpinned by augmented β cell function and coordinated activity across the islet. These effects involve changes in circulating GLP-1 levels which may act both directly and indirectly on the β cell, in the latter case through changes in body weight. Thus, bariatric surgery leads to time-dependent increases in β cell function and intra-islet connectivity which are likely to contribute to diabetes remission.

Date: 2021
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DOI: 10.1038/s41467-021-25423-8

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