BMP8 and activated brown adipose tissue in human newborns

Adela Urisarri, Ismael González-García, Ánxela Estévez-Salguero, María P. Pata, Edward Milbank, Noemi López, Natalia Mandiá, Carmen Grijota-Martinez, Carlos A. Salgado, Rubén Nogueiras, Carlos Diéguez, Francesc Villarroya, José-Manuel Fernández-Real, María L. Couce () and Miguel López ()
Additional contact information
Adela Urisarri: University Clinical Hospital of Santiago de Compostela, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), CIBER Enfermedades Raras (CIBERER), Travesia Choupana
Ismael González-García: University of Santiago de Compostela–Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)
Ánxela Estévez-Salguero: University of Santiago de Compostela–Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)
María P. Pata: Biostatech Advice, Training and Innovation in Biostatistics
Edward Milbank: University of Santiago de Compostela–Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)
Noemi López: University Clinical Hospital of Santiago de Compostela, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), CIBER Enfermedades Raras (CIBERER), Travesia Choupana
Natalia Mandiá: University Clinical Hospital of Santiago de Compostela, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), CIBER Enfermedades Raras (CIBERER), Travesia Choupana
Carmen Grijota-Martinez: Faculty of Biology, Complutense University
Carlos A. Salgado: University of Santiago de Compostela
Rubén Nogueiras: University of Santiago de Compostela–Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)
Carlos Diéguez: University of Santiago de Compostela–Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)
Francesc Villarroya: CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn)
José-Manuel Fernández-Real: CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn)
María L. Couce: University Clinical Hospital of Santiago de Compostela, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), CIBER Enfermedades Raras (CIBERER), Travesia Choupana
Miguel López: University of Santiago de Compostela–Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract The classical dogma states that brown adipose tissue (BAT) plays a major role in the regulation of temperature in neonates. However, although BAT has been studied in infants for more than a century, the knowledge about its physiological features at this stage of life is rather limited. This has been mainly due to the lack of appropriate investigation methods, ethically suitable for neonates. Here, we have applied non-invasive infrared thermography (IRT) to investigate neonatal BAT activity. Our data show that BAT temperature correlates with body temperature and that mild cold stimulus promotes BAT activation in newborns. Notably, a single short-term cold stimulus during the first day of life improves the body temperature adaption to a subsequent cold event. Finally, we identify that bone morphogenic protein 8B (BMP8B) is associated with the BAT thermogenic response in neonates. Overall, our data uncover key features of the setup of BAT thermogenesis in newborns.

Date: 2021
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DOI: 10.1038/s41467-021-25456-z

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