Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer

Kerui Wu, Jiamei Feng, Feng Lyu, Fei Xing, Sambad Sharma, Yin Liu, Shih-Ying Wu, Dan Zhao, Abhishek Tyagi, Ravindra Pramod Deshpande, Xinhong Pei, Marco Gabril Ruiz, Hiroyuki Takahashi, Shunsuke Tsuzuki, Takahiro Kimura, Yin-yuan Mo, Yusuke Shiozawa, Ravi Singh and Kounosuke Watabe ()
Additional contact information
Kerui Wu: Wake Forest University School of Medicine
Jiamei Feng: Wake Forest University School of Medicine
Feng Lyu: Wake Forest University School of Medicine
Fei Xing: Wake Forest University School of Medicine
Sambad Sharma: Wake Forest University School of Medicine
Yin Liu: Wake Forest University School of Medicine
Shih-Ying Wu: Wake Forest University School of Medicine
Dan Zhao: Wake Forest University School of Medicine
Abhishek Tyagi: Wake Forest University School of Medicine
Ravindra Pramod Deshpande: Wake Forest University School of Medicine
Xinhong Pei: Wake Forest University School of Medicine
Marco Gabril Ruiz: Wake Forest University School of Medicine
Hiroyuki Takahashi: Jikei University School of Medicine
Shunsuke Tsuzuki: Jikei University School of Medicine
Takahiro Kimura: Jikei University School of Medicine
Yin-yuan Mo: University of Mississippi Medical Center
Yusuke Shiozawa: Wake Forest University School of Medicine
Ravi Singh: Wake Forest University School of Medicine
Kounosuke Watabe: Wake Forest University School of Medicine

Nature Communications, 2021, vol. 12, issue 1, 1-18

Abstract: Abstract Bone metastasis is an incurable complication of breast cancer. In advanced stages, patients with estrogen-positive tumors experience a significantly higher incidence of bone metastasis (>87%) compared to estrogen-negative patients (

Date: 2021
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DOI: 10.1038/s41467-021-25473-y

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