Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysis

Xiannian Zhang, Linna Peng, Yingying Luo, Shaosen Zhang, Yang Pu, Yamei Chen, Wenjia Guo, Jiacheng Yao, Mingming Shao, Wenyi Fan, Qionghua Cui, Yiyi Xi, Yanxia Sun, Xiangjie Niu, Xuan Zhao, Liping Chen, Yuqian Wang, Yachen Liu, Xinyu Yang, Chengcheng Wang, Ce Zhong, Wen Tan, Jianbin Wang (), Chen Wu () and Dongxin Lin
Additional contact information
Xiannian Zhang: Capital Medical University
Linna Peng: Chinese Academy of Medical Sciences and Peking Union Medical College
Yingying Luo: Chinese Academy of Medical Sciences and Peking Union Medical College
Shaosen Zhang: Chinese Academy of Medical Sciences and Peking Union Medical College
Yang Pu: Chinese Academy of Medical Sciences and Peking Union Medical College
Yamei Chen: Chinese Academy of Medical Sciences and Peking Union Medical College
Wenjia Guo: Affiliated Cancer Hospital of Xinjiang Medical University
Jiacheng Yao: Tsinghua University
Mingming Shao: Chinese Academy of Medical Sciences and Peking Union Medical College
Wenyi Fan: Chinese Academy of Medical Sciences and Peking Union Medical College
Qionghua Cui: Chinese Academy of Medical Sciences and Peking Union Medical College
Yiyi Xi: Chinese Academy of Medical Sciences and Peking Union Medical College
Yanxia Sun: Chinese Academy of Medical Sciences and Peking Union Medical College
Xiangjie Niu: Chinese Academy of Medical Sciences and Peking Union Medical College
Xuan Zhao: Chinese Academy of Medical Sciences and Peking Union Medical College
Liping Chen: Chinese Academy of Medical Sciences and Peking Union Medical College
Yuqian Wang: Chinese Academy of Medical Sciences and Peking Union Medical College
Yachen Liu: Chinese Academy of Medical Sciences and Peking Union Medical College
Xinyu Yang: Chinese Academy of Medical Sciences and Peking Union Medical College
Chengcheng Wang: Chinese Academy of Medical Sciences and Peking Union Medical College
Ce Zhong: Chinese Academy of Medical Sciences and Peking Union Medical College
Wen Tan: Chinese Academy of Medical Sciences and Peking Union Medical College
Jianbin Wang: Tsinghua University
Chen Wu: Chinese Academy of Medical Sciences and Peking Union Medical College
Dongxin Lin: Chinese Academy of Medical Sciences and Peking Union Medical College

Nature Communications, 2021, vol. 12, issue 1, 1-17

Abstract: Abstract Esophageal squamous-cell carcinoma (ESCC), one of the most prevalent and lethal malignant disease, has a complex but unknown tumor ecosystem. Here, we investigate the composition of ESCC tumors based on 208,659 single-cell transcriptomes derived from 60 individuals. We identify 8 common expression programs from malignant epithelial cells and discover 42 cell types, including 26 immune cell and 16 nonimmune stromal cell subtypes in the tumor microenvironment (TME), and analyse the interactions between cancer cells and other cells and the interactions among different cell types in the TME. Moreover, we link the cancer cell transcriptomes to the somatic mutations and identify several markers significantly associated with patients’ survival, which may be relevant to precision care of ESCC patients. These results reveal the immunosuppressive status in the ESCC TME and further our understanding of ESCC.

Date: 2021
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DOI: 10.1038/s41467-021-25539-x

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