The Arabidopsis MIK2 receptor elicits immunity by sensing a conserved signature from phytocytokines and microbes

Shuguo Hou (), Derui Liu, Shijia Huang, Dexian Luo, Zunyong Liu, Qingyuan Xiang, Ping Wang, Ruimin Mu, Zhifu Han, Sixue Chen, Jijie Chai, Libo Shan () and Ping He ()
Additional contact information
Shuguo Hou: Shandong Jianzhu University
Derui Liu: Texas A&M University
Shijia Huang: Tsinghua University
Dexian Luo: Texas A&M University
Zunyong Liu: Texas A&M University
Qingyuan Xiang: University of Florida
Ping Wang: Texas A&M University
Ruimin Mu: Shandong Jianzhu University
Zhifu Han: Tsinghua University
Sixue Chen: University of Florida
Jijie Chai: Tsinghua University
Libo Shan: Texas A&M University
Ping He: Texas A&M University

Nature Communications, 2021, vol. 12, issue 1, 1-15

Abstract: Abstract Sessile plants encode a large number of small peptides and cell surface-resident receptor kinases, most of which have unknown functions. Here, we report that the Arabidopsis receptor kinase MALE DISCOVERER 1-INTERACTING RECEPTOR-LIKE KINASE 2 (MIK2) recognizes the conserved signature motif of SERINE-RICH ENDOGENOUS PEPTIDEs (SCOOPs) from Brassicaceae plants as well as proteins present in fungal Fusarium spp. and bacterial Comamonadaceae, and elicits various immune responses. SCOOP signature peptides trigger immune responses and altered root development in a MIK2-dependent manner with a sub-nanomolar sensitivity. SCOOP12 directly binds to the extracellular leucine-rich repeat domain of MIK2 in vivo and in vitro, indicating that MIK2 is the receptor of SCOOP peptides. Perception of SCOOP peptides induces the association of MIK2 and the coreceptors SOMATIC EMBRYOGENESIS RECEPTOR KINASE 3 (SERK3) and SERK4 and relays the signaling through the cytosolic receptor-like kinases BOTRYTIS-INDUCED KINASE 1 (BIK1) and AVRPPHB SUSCEPTIBLE1 (PBS1)-LIKE 1 (PBL1). Our study identifies a plant receptor that bears a dual role in sensing the conserved peptide motif from phytocytokines and microbial proteins via a convergent signaling relay to ensure a robust immune response.

Date: 2021
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DOI: 10.1038/s41467-021-25580-w

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