Bio-inspired poly-DL-serine materials resist the foreign-body response

Donghui Zhang, Qi Chen, Yufang Bi, Haodong Zhang, Minzhang Chen, Jianglin Wan, Chao Shi, Wenjing Zhang, Junyu Zhang, Zhongqian Qiao, Jin Li, Shengfu Chen and Runhui Liu ()
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Donghui Zhang: East China University of Science and Technology
Qi Chen: Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology
Yufang Bi: Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology
Haodong Zhang: Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology
Minzhang Chen: Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology
Jianglin Wan: Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology
Chao Shi: Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology
Wenjing Zhang: Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology
Junyu Zhang: Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology
Zhongqian Qiao: Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology
Jin Li: Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
Shengfu Chen: College of Chemical and Biological Engineering, Zhejiang University
Runhui Liu: East China University of Science and Technology

Nature Communications, 2021, vol. 12, issue 1, 1-12

Abstract: Abstract Implantation-caused foreign-body response (FBR) is a commonly encountered issue and can result in failure of implants. The high L-serine content in low immunogenic silk sericin, and the high D-serine content as a neurotransmitter together inspire us to prepare poly-DL-serine (PSer) materials in mitigating the FBR. Here we report highly water soluble, biocompatible and easily accessible PSer hydrogels that cause negligible inflammatory response after subcutaneous implantation in mice for 1 week and 2 weeks. No obvious collagen capsulation is found surrounding the PSer hydrogels after 4 weeks, 3 months and 7 months post implantation. Histological analysis on inflammatory cytokines and RNA-seq assay both indicate that PSer hydrogels show low FBR, comparable to the Mock group. The anti-FBR performance of PSer hydrogels at all time points surpass the poly(ethyleneglycol) hydrogels that is widely utilized as bio-inert materials, implying the potent and wide application of PSer materials in implantable biomaterials and biomedical devices.

Date: 2021
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DOI: 10.1038/s41467-021-25581-9

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