A bacterial kinase phosphorylates OSK1 to suppress stomatal immunity in rice

Shanzhi Wang, Shuai Li, Jiyang Wang, Qian Li, Xiu-Fang Xin, Shuang Zhou, Yanping Wang, Dayong Li, Jiaqing Xu, Zhao-Qing Luo, Sheng Yang He and Wenxian Sun ()
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Shanzhi Wang: China Agricultural University
Shuai Li: China Agricultural University
Jiyang Wang: China Agricultural University
Qian Li: China Agricultural University
Xiu-Fang Xin: Michigan State University
Shuang Zhou: China Agricultural University
Yanping Wang: China Agricultural University
Dayong Li: Jilin Agricultural University
Jiaqing Xu: China Agricultural University
Zhao-Qing Luo: Purdue Institute for Inflammation, Immunology and Infectious Disease and Department of Biological Sciences, Purdue University
Sheng Yang He: Michigan State University
Wenxian Sun: China Agricultural University

Nature Communications, 2021, vol. 12, issue 1, 1-15

Abstract: Abstract The Xanthomonas outer protein C2 (XopC2) family of bacterial effectors is widely found in plant pathogens and Legionella species. However, the biochemical activity and host targets of these effectors remain enigmatic. Here we show that ectopic expression of XopC2 promotes jasmonate signaling and stomatal opening in transgenic rice plants, which are more susceptible to Xanthomonas oryzae pv. oryzicola infection. Guided by these phenotypes, we discover that XopC2 represents a family of atypical kinases that specifically phosphorylate OSK1, a universal adaptor protein of the Skp1-Cullin-F-box ubiquitin ligase complexes. Intriguingly, OSK1 phosphorylation at Ser53 by XopC2 exclusively increases the binding affinity of OSK1 to the jasmonate receptor OsCOI1b, and specifically enhances the ubiquitination and degradation of JAZ transcription repressors and plant disease susceptibility through inhibiting stomatal immunity. These results define XopC2 as a prototypic member of a family of pathogenic effector kinases and highlight a smart molecular mechanism to activate jasmonate signaling.

Date: 2021
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DOI: 10.1038/s41467-021-25748-4

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