Spatially and optically tailored 3D printing for highly miniaturized and integrated microfluidics

Jose L. Sanchez Noriega, Nicholas A. Chartrand, Jonard Corpuz Valdoz, Collin G. Cribbs, Dallin A. Jacobs, Daniel Poulson, Matthew S. Viglione, Adam T. Woolley, Pam M. Ry, Kenneth A. Christensen and Gregory P. Nordin ()
Additional contact information
Jose L. Sanchez Noriega: Brigham Young University
Nicholas A. Chartrand: Brigham Young University
Jonard Corpuz Valdoz: Brigham Young University
Collin G. Cribbs: Brigham Young University
Dallin A. Jacobs: Brigham Young University
Daniel Poulson: Brigham Young University
Matthew S. Viglione: Brigham Young University
Adam T. Woolley: Brigham Young University
Pam M. Ry: Brigham Young University
Kenneth A. Christensen: Brigham Young University
Gregory P. Nordin: Brigham Young University

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract Traditional 3D printing based on Digital Light Processing Stereolithography (DLP-SL) is unnecessarily limiting as applied to microfluidic device fabrication, especially for high-resolution features. This limitation is due primarily to inherent tradeoffs between layer thickness, exposure time, material strength, and optical penetration that can be impossible to satisfy for microfluidic features. We introduce a generalized 3D printing process that significantly expands the accessible spatially distributed optical dose parameter space to enable the fabrication of much higher resolution 3D components without increasing the resolution of the 3D printer. Here we demonstrate component miniaturization in conjunction with a high degree of integration, including 15 μm × 15 μm valves and a 2.2 mm × 1.1 mm 10-stage 2-fold serial diluter. These results illustrate our approach’s promise to enable highly functional and compact microfluidic devices for a wide variety of biomolecular applications.

Date: 2021
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DOI: 10.1038/s41467-021-25788-w

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