A novel nairovirus associated with acute febrile illness in Hokkaido, Japan

Fumihiro Kodama, Hiroki Yamaguchi, Eunsil Park, Kango Tatemoto, Mariko Sashika, Ryo Nakao, Yurino Terauchi, Keita Mizuma, Yasuko Orba, Hiroaki Kariwa, Katsuro Hagiwara, Katsunori Okazaki, Akiko Goto, Rika Komagome, Masahiro Miyoshi, Takuya Ito, Kimiaki Yamano, Kentaro Yoshii, Chiaki Funaki, Mariko Ishizuka, Asako Shigeno, Yukari Itakura, Lesley Bell-Sakyi, Shunji Edagawa, Atsushi Nagasaka, Yoshihiro Sakoda, Hirofumi Sawa, Ken Maeda, Masayuki Saijo and Keita Matsuno ()
Additional contact information
Fumihiro Kodama: Sapporo City General Hospital
Hiroki Yamaguchi: Hokkaido Institute of Public Health
Eunsil Park: National Institute of Infectious Diseases
Kango Tatemoto: National Institute of Infectious Diseases
Mariko Sashika: Hokkaido University
Ryo Nakao: Hokkaido University
Yurino Terauchi: Hokkaido University
Keita Mizuma: Hokkaido University
Yasuko Orba: Hokkaido University
Hiroaki Kariwa: Hokkaido University
Katsuro Hagiwara: Rakuno Gakuen University
Katsunori Okazaki: Health Sciences University of Hokkaido
Akiko Goto: Hokkaido Institute of Public Health
Rika Komagome: Hokkaido Institute of Public Health
Masahiro Miyoshi: Hokkaido Institute of Public Health
Takuya Ito: Hokkaido Institute of Public Health
Kimiaki Yamano: Hokkaido Institute of Public Health
Kentaro Yoshii: Nagasaki University
Chiaki Funaki: Hokkaido University
Mariko Ishizuka: Hokkaido University
Asako Shigeno: Hokkaido University
Yukari Itakura: Hokkaido University
Lesley Bell-Sakyi: University of Liverpool
Shunji Edagawa: Sapporo City General Hospital
Atsushi Nagasaka: Sapporo City General Hospital
Yoshihiro Sakoda: Hokkaido University
Hirofumi Sawa: Hokkaido University
Ken Maeda: National Institute of Infectious Diseases
Masayuki Saijo: National Institute of Infectious Diseases
Keita Matsuno: Hokkaido University

Nature Communications, 2021, vol. 12, issue 1, 1-9

Abstract: Abstract The increasing burden of tick-borne orthonairovirus infections, such as Crimean-Congo hemorrhagic fever, is becoming a global concern for public health. In the present study, we identify a novel orthonairovirus, designated Yezo virus (YEZV), from two patients showing acute febrile illness with thrombocytopenia and leukopenia after tick bite in Hokkaido, Japan, in 2019 and 2020, respectively. YEZV is phylogenetically grouped with Sulina virus detected in Ixodes ricinus ticks in Romania. YEZV infection has been confirmed in seven patients from 2014–2020, four of whom were co-infected with Borrelia spp. Antibodies to YEZV are found in wild deer and raccoons, and YEZV RNAs have been detected in ticks from Hokkaido. In this work, we demonstrate that YEZV is highly likely to be the causative pathogen of febrile illness, representing the first report of an endemic infection associated with an orthonairovirus potentially transmitted by ticks in Japan.

Date: 2021
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DOI: 10.1038/s41467-021-25857-0

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