SARS-CoV-2 mucosal antibody development and persistence and their relation to viral load and COVID-19 symptoms

Janeri Fröberg, Joshua Gillard, Ria Philipsen, Kjerstin Lanke, Joyce Rust, Diana Tuijl, Karina Teelen, Teun Bousema, Elles Simonetti, Christa E. Gaast- de Jongh, Mariska Bos, Frank J. Kuppeveld, Berend-Jan Bosch, Marrigje Nabuurs-Franssen, Nannet Geest-Blankert, Charlotte Daal, Martijn A. Huynen, Marien I. Jonge and Dimitri A. Diavatopoulos ()
Additional contact information
Janeri Fröberg: Radboud University Medical Centre, Radboud Institute for Molecular Life Sciences, Laboratory of Medical Immunology, Section Paediatric Infectious Diseases
Joshua Gillard: Radboud University Medical Centre, Radboud Institute for Molecular Life Sciences, Laboratory of Medical Immunology, Section Paediatric Infectious Diseases
Ria Philipsen: Radboud University Medical Centre, Radboud Institute for Molecular Life Sciences, Laboratory of Medical Immunology, Section Paediatric Infectious Diseases
Kjerstin Lanke: Radboud Center for Infectious Diseases, Radboudumc
Joyce Rust: Radboud University Medical Centre, Radboud Institute for Molecular Life Sciences, Laboratory of Medical Immunology, Section Paediatric Infectious Diseases
Diana Tuijl: Radboud University Medical Centre, Radboud Institute for Molecular Life Sciences, Laboratory of Medical Immunology, Section Paediatric Infectious Diseases
Karina Teelen: Radboud Center for Infectious Diseases, Radboudumc
Teun Bousema: Radboud Center for Infectious Diseases, Radboudumc
Elles Simonetti: Radboud University Medical Centre, Radboud Institute for Molecular Life Sciences, Laboratory of Medical Immunology, Section Paediatric Infectious Diseases
Christa E. Gaast- de Jongh: Radboud University Medical Centre, Radboud Institute for Molecular Life Sciences, Laboratory of Medical Immunology, Section Paediatric Infectious Diseases
Mariska Bos: Radboud University Medical Centre, Radboud Institute for Molecular Life Sciences, Laboratory of Medical Immunology, Section Paediatric Infectious Diseases
Frank J. Kuppeveld: Utrecht University, Faculty of Veterinary Medicine, Department of Biomolecular Health Sciences, Division Infectious Diseases and Immunology
Berend-Jan Bosch: Utrecht University, Faculty of Veterinary Medicine, Department of Biomolecular Health Sciences, Division Infectious Diseases and Immunology
Marrigje Nabuurs-Franssen: Canisius Wilhelmina Hospital
Nannet Geest-Blankert: Radboud University Medical Centre
Charlotte Daal: Radboud University Medical Centre
Martijn A. Huynen: Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre Nijmegen
Marien I. Jonge: Radboud University Medical Centre, Radboud Institute for Molecular Life Sciences, Laboratory of Medical Immunology, Section Paediatric Infectious Diseases
Dimitri A. Diavatopoulos: Radboud University Medical Centre, Radboud Institute for Molecular Life Sciences, Laboratory of Medical Immunology, Section Paediatric Infectious Diseases

Nature Communications, 2021, vol. 12, issue 1, 1-11

Abstract: Abstract Although serological studies have shown that antibodies against SARS-CoV-2 play an important role in protection against (re)infection, the dynamics of mucosal antibodies during primary infection and their potential impact on viral load and the resolution of disease symptoms remain unclear. During the first pandemic wave, we assessed the longitudinal nasal antibody response in index cases with mild COVID-19 and their household contacts. Nasal and serum antibody responses were analysed for up to nine months. Higher nasal receptor binding domain and spike protein-specific antibody levels at study inclusion were associated with lower viral load. Older age was correlated with more frequent COVID-19 related symptoms. Receptor binding domain and spike protein-specific mucosal antibodies were associated with the resolution of systemic, but not respiratory symptoms. Finally, receptor binding domain and spike protein-specific mucosal antibodies remained elevated up to nine months after symptom onset.

Date: 2021
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-021-25949-x Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25949-x

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-021-25949-x

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().