Stage-resolved Hi-C analyses reveal meiotic chromosome organizational features influencing homolog alignment

Wu Zuo, Guangming Chen, Zhimei Gao, Shuai Li, Yanyan Chen, Chenhui Huang, Juan Chen, Zhengjun Chen, Ming Lei () and Qian Bian ()
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Wu Zuo: Chinese Academy of Sciences
Guangming Chen: Shanghai Jiao Tong University School of Medicine
Zhimei Gao: Shanghai Jiao Tong University School of Medicine
Shuai Li: Shanghai Jiao Tong University School of Medicine
Yanyan Chen: Shanghai Jiao Tong University School of Medicine
Chenhui Huang: Shanghai Jiao Tong University School of Medicine
Juan Chen: Shanghai Jiao Tong University School of Medicine
Zhengjun Chen: Chinese Academy of Sciences
Ming Lei: Shanghai Jiao Tong University School of Medicine
Qian Bian: Shanghai Jiao Tong University School of Medicine

Nature Communications, 2021, vol. 12, issue 1, 1-20

Abstract: Abstract During meiosis, chromosomes exhibit dramatic changes in morphology and intranuclear positioning. How these changes influence homolog pairing, alignment, and recombination remain elusive. Using Hi-C, we systematically mapped 3D genome architecture throughout all meiotic prophase substages during mouse spermatogenesis. Our data uncover two major chromosome organizational features varying along the chromosome axis during early meiotic prophase, when homolog alignment occurs. First, transcriptionally active and inactive genomic regions form alternating domains consisting of shorter and longer chromatin loops, respectively. Second, the force-transmitting LINC complex promotes the alignment of ends of different chromosomes over a range of up to 20% of chromosome length. Both features correlate with the pattern of homolog interactions and the distribution of recombination events. Collectively, our data reveal the influences of transcription and force on meiotic chromosome structure and suggest chromosome organization may provide an infrastructure for the modulation of meiotic recombination in higher eukaryotes.

Date: 2021
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DOI: 10.1038/s41467-021-26033-0

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