Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination

Mads Delbo Larsen, Mary Lopez-Perez, Emmanuel Kakra Dickson, Paulina Ampomah, Nicaise Tuikue Ndam, Jan Nouta, Carolien A. M. Koeleman, Agnes L. Hipgrave Ederveen, Benjamin Mordmüller, Ali Salanti, Morten Agertoug Nielsen, Achille Massougbodji, C. Ellen Schoot, Michael F. Ofori, Manfred Wuhrer, Lars Hviid () and Gestur Vidarsson ()
Additional contact information
Mads Delbo Larsen: Sanquin Research
Mary Lopez-Perez: University of Copenhagen
Emmanuel Kakra Dickson: University of Ghana
Paulina Ampomah: University of Cape Coast
Nicaise Tuikue Ndam: Université de Paris, MERIT, IRD
Jan Nouta: Leiden University Medical Center
Carolien A. M. Koeleman: Leiden University Medical Center
Agnes L. Hipgrave Ederveen: Leiden University Medical Center
Benjamin Mordmüller: Radboud University Medical Center
Ali Salanti: University of Copenhagen
Morten Agertoug Nielsen: University of Copenhagen
Achille Massougbodji: Université d’Abomey-Calavi
C. Ellen Schoot: Sanquin Research
Michael F. Ofori: University of Ghana
Manfred Wuhrer: Leiden University Medical Center
Lars Hviid: University of Copenhagen
Gestur Vidarsson: Sanquin Research

Nature Communications, 2021, vol. 12, issue 1, 1-10

Abstract: Abstract Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family members mediate receptor- and tissue-specific sequestration of infected erythrocytes (IEs) in malaria. Antibody responses are a central component of naturally acquired malaria immunity. PfEMP1-specific IgG likely protects by inhibiting IE sequestration and through IgG-Fc Receptor (FcγR) mediated phagocytosis and killing of antibody-opsonized IEs. The affinity of afucosylated IgG to FcγRIIIa is up to 40-fold higher than fucosylated IgG, resulting in enhanced antibody-dependent cellular cytotoxicity. Most IgG in plasma is fully fucosylated, but afucosylated IgG is elicited in response to enveloped viruses and to paternal alloantigens during pregnancy. Here we show that naturally acquired PfEMP1-specific IgG is strongly afucosylated in a stable and exposure-dependent manner, and efficiently induces FcγRIIIa-dependent natural killer (NK) cell degranulation. In contrast, immunization with a subunit PfEMP1 (VAR2CSA) vaccine results in fully fucosylated specific IgG. These results have implications for understanding protective natural- and vaccine-induced immunity to malaria.

Date: 2021
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/s41467-021-26118-w Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26118-w

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-021-26118-w

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().