Addressing MRSA infection and antibacterial resistance with peptoid polymers

Jiayang Xie, Min Zhou, Yuxin Qian, Zihao Cong, Sheng Chen, Wenjing Zhang, Weinan Jiang, Chengzhi Dai, Ning Shao, Zhemin Ji, Jingcheng Zou, Ximian Xiao, Longqiang Liu, Minzhang Chen, Jin Li and Runhui Liu ()
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Jiayang Xie: East China University of Science and Technology
Min Zhou: East China University of Science and Technology
Yuxin Qian: East China University of Science and Technology
Zihao Cong: East China University of Science and Technology
Sheng Chen: East China University of Science and Technology
Wenjing Zhang: East China University of Science and Technology
Weinan Jiang: East China University of Science and Technology
Chengzhi Dai: East China University of Science and Technology
Ning Shao: East China University of Science and Technology
Zhemin Ji: East China University of Science and Technology
Jingcheng Zou: East China University of Science and Technology
Ximian Xiao: East China University of Science and Technology
Longqiang Liu: East China University of Science and Technology
Minzhang Chen: East China University of Science and Technology
Jin Li: Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
Runhui Liu: East China University of Science and Technology

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract Methicillin-Resistant Staphylococcus aureus (MRSA) induced infection calls for antibacterial agents that are not prone to antimicrobial resistance. We prepare protease-resistant peptoid polymers with variable C-terminal functional groups using a ring-opening polymerization of N-substituted N-carboxyanhydrides (NNCA), which can provide peptoid polymers easily from the one-pot synthesis. We study the optimal polymer that displays effective activity against MRSA planktonic and persister cells, effective eradication of highly antibiotic-resistant MRSA biofilms, and potent anti-infectious performance in vivo using the wound infection model, the mouse keratitis model, and the mouse peritonitis model. Peptoid polymers show insusceptibility to antimicrobial resistance, which is a prominent merit of these antimicrobial agents. The low cost, convenient synthesis and structure diversity of peptoid polymers, the superior antimicrobial performance and therapeutic potential in treating MRSA infection altogether imply great potential of peptoid polymers as promising antibacterial agents in treating MRSA infection and alleviating antibiotic resistance.

Date: 2021
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DOI: 10.1038/s41467-021-26221-y

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