Robust hemostatic bandages based on nanoclay electrospun membranes

Yan Cui, Zongwang Huang, Li Lei, Qinglin Li, Jinlong Jiang, Qinghai Zeng, Aidong Tang, Huaming Yang and Yi Zhang ()
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Yan Cui: Central South University
Zongwang Huang: Central South University
Li Lei: the Third Xiangya Hospital, Central South University
Qinglin Li: Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)
Jinlong Jiang: Huaiyin Institute of Technology
Qinghai Zeng: the Third Xiangya Hospital, Central South University
Aidong Tang: Central South University
Huaming Yang: Central South University
Yi Zhang: Central South University

Nature Communications, 2021, vol. 12, issue 1, 1-11

Abstract: Abstract Death from acute hemorrhage is a major problem in military conflicts, traffic accidents, and surgical procedures, et al. Achieving rapid effective hemostasis for pre-hospital care is essential to save lives in massive bleeding. An ideal hemostasis material should have those features such as safe, efficient, convenient, economical, which remains challenging and most of them cannot be achieved at the same time. In this work, we report a rapid effective nanoclay-based hemostatic membranes with nanoclay particles incorporate into polyvinylpyrrolidone (PVP) electrospun fibers. The nanoclay electrospun membrane (NEM) with 60 wt% kaolinite (KEM1.5) shows better and faster hemostatic performance in vitro and in vivo with good biocompatibility compared with most other NEMs and clay-based hemostats, benefiting from its enriched hemostatic functional sites, robust fluffy framework, and hydrophilic surface. The robust hemostatic bandages based on nanoclay electrospun membrane is an effective candidate hemostat in practical application.

Date: 2021
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DOI: 10.1038/s41467-021-26237-4

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