Context value updating and multidimensional neuronal encoding in the retrosplenial cortex

Weilun Sun, Ilseob Choi, Stoyan Stoyanov, Oleg Senkov, Evgeni Ponimaskin, York Winter, Janelle M. P. Pakan () and Alexander Dityatev ()
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Weilun Sun: Molecular Neuroplasticity, German Center for Neurodegenerative Diseases (DZNE)
Ilseob Choi: Molecular Neuroplasticity, German Center for Neurodegenerative Diseases (DZNE)
Stoyan Stoyanov: Molecular Neuroplasticity, German Center for Neurodegenerative Diseases (DZNE)
Oleg Senkov: Molecular Neuroplasticity, German Center for Neurodegenerative Diseases (DZNE)
Evgeni Ponimaskin: Hannover Medical School
York Winter: Humboldt University
Janelle M. P. Pakan: Center for Behavioral Brain Sciences (CBBS)
Alexander Dityatev: Molecular Neuroplasticity, German Center for Neurodegenerative Diseases (DZNE)

Nature Communications, 2021, vol. 12, issue 1, 1-17

Abstract: Abstract The retrosplenial cortex (RSC) has diverse functional inputs and is engaged by various sensory, spatial, and associative learning tasks. We examine how multiple functional aspects are integrated on the single-cell level in the RSC and how the encoding of task-related parameters changes across learning. Using a visuospatial context discrimination paradigm and two-photon calcium imaging in behaving mice, a large proportion of dysgranular RSC neurons was found to encode multiple task-related dimensions while forming context-value associations across learning. During reversal learning requiring increased cognitive flexibility, we revealed an increased proportion of multidimensional encoding neurons that showed higher decoding accuracy for behaviorally relevant context-value associations. Chemogenetic inactivation of RSC led to decreased behavioral context discrimination during learning phases in which context-value associations were formed, while recall of previously formed associations remained intact. RSC inactivation resulted in a persistent positive behavioral bias in valuing contexts, indicating a role for the RSC in context-value updating.

Date: 2021
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DOI: 10.1038/s41467-021-26301-z

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