Lateralization of CA1 assemblies in the absence of CA3 input

Hefei Guan, Steven J. Middleton, Takafumi Inoue and Thomas J. McHugh ()
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Hefei Guan: RIKEN Center for Brain Science
Steven J. Middleton: RIKEN Center for Brain Science
Takafumi Inoue: School of Advanced Science and Engineering, Waseda University
Thomas J. McHugh: RIKEN Center for Brain Science

Nature Communications, 2021, vol. 12, issue 1, 1-10

Abstract: Abstract In the hippocampal circuit CA3 input plays a critical role in the organization of CA1 population activity, both during learning and sleep. While integrated spatial representations have been observed across the two hemispheres of CA1, these regions lack direct connectivity and thus the circuitry responsible remains largely unexplored. Here we investigate the role of CA3 in organizing bilateral CA1 activity by blocking synaptic transmission at CA3 terminals through the inducible transgenic expression of tetanus toxin. Although the properties of single place cells in CA1 were comparable bilaterally, we find a decrease of ripple synchronization between left and right CA1 after silencing CA3. Further, during both exploration and rest, CA1 neuronal ensemble activity is less coordinated across hemispheres. This included degradation of the replay of previously explored spatial paths in CA1 during rest, consistent with the idea that CA3 bilateral projections integrate activity between left and right hemispheres and orchestrate bilateral hippocampal coding.

Date: 2021
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DOI: 10.1038/s41467-021-26389-3

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