Aggregation-induced emission luminogens for image-guided surgery in non-human primates

Danni Zhong, Weiyu Chen, Zhiming Xia, Rong Hu, Yuchen Qi, Bo Zhou, Wanlin Li, Jian He, Zhiming Wang, Zujin Zhao, Dan Ding, Mei Tian, Ben Zhong Tang () and Min Zhou ()
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Danni Zhong: Zhejiang University School of Medicine
Weiyu Chen: Zhejiang University School of Medicine
Zhiming Xia: Shandong Provincial Hospital Affiliated to Shandong First Medical University
Rong Hu: South China University of Technology
Yuchen Qi: Zhejiang University
Bo Zhou: Zhejiang University
Wanlin Li: Zhejiang University
Jian He: Zhejiang University
Zhiming Wang: South China University of Technology
Zujin Zhao: South China University of Technology
Dan Ding: Nankai University
Mei Tian: Zhejiang University School of Medicine
Ben Zhong Tang: South China University of Technology
Min Zhou: Zhejiang University School of Medicine

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract During the past two decades, aggregation-induced emission luminogens (AIEgens) have been intensively exploited for biological and biomedical applications. Although a series of investigations have been performed in non-primate animal models, there is few pilot studies in non-human primate animal models, strongly hindering the clinical translation of AIE luminogens (AIEgens). Herein, we present a systemic and multifaceted demonstration of an optical imaging-guided surgical operation via AIEgens from small animals (e.g., mice and rabbits) to rhesus macaque, the typical non-human primate animal model. Specifically, the folic conjugated-AIE luminogen (folic-AIEgen) generates strong and stable fluorescence for the detection and surgical excision of sentinel lymph nodes (SLNs). Moreover, with the superior tumor/normal tissue ratio and rapid tumor accumulation, folic-AIEgen successfully images and guides the precise resection of invisible cancerous metastases. Taken together, the presented strategies of folic-AIEgen based fluorescence intraoperative imaging and visualization-guided surgery show potential for clinical applications.

Date: 2021
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DOI: 10.1038/s41467-021-26417-2

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