Daily caloric restriction limits tumor growth more effectively than caloric cycling regardless of dietary composition

Laura C. D. Pomatto-Watson, Monica Bodogai, Oye Bosompra, Jonathan Kato, Sarah Wong, Melissa Carpenter, Eleonora Duregon, Dolly Chowdhury, Priya Krishna, Sandy Ng, Emeline Ragonnaud, Roberto Salgado, Paula Gonzalez Ericsson, Alberto Diaz-Ruiz, Michel Bernier, Nathan L. Price, Arya Biragyn, Valter D. Longo and Rafael de Cabo ()
Additional contact information
Laura C. D. Pomatto-Watson: National Institutes of Health
Monica Bodogai: National Institute on Aging, National Institutes of Health
Oye Bosompra: National Institutes of Health
Jonathan Kato: National Institutes of Health
Sarah Wong: National Institutes of Health
Melissa Carpenter: National Institutes of Health
Eleonora Duregon: National Institutes of Health
Dolly Chowdhury: National Institutes of Health
Priya Krishna: National Institutes of Health
Sandy Ng: National Institutes of Health
Emeline Ragonnaud: National Institute on Aging, National Institutes of Health
Roberto Salgado: GZA-ZNA Hospitals
Paula Gonzalez Ericsson: Vanderbilt University Medical Center
Alberto Diaz-Ruiz: IMDEA Food
Michel Bernier: National Institutes of Health
Nathan L. Price: National Institutes of Health
Arya Biragyn: National Institute on Aging, National Institutes of Health
Valter D. Longo: University of Southern California
Rafael de Cabo: National Institutes of Health

Nature Communications, 2021, vol. 12, issue 1, 1-17

Abstract: Abstract Cancer incidence increases with age and is a leading cause of death. Caloric restriction (CR) confers benefits on health and survival and delays cancer. However, due to CR’s stringency, dietary alternatives offering the same cancer protection have become increasingly attractive. Short cycles of a plant-based diet designed to mimic fasting (FMD) are protective against tumorigenesis without the chronic restriction of calories. Yet, it is unclear whether the fasting time, level of dietary restriction, or nutrient composition is the primary driver behind cancer protection. Using a breast cancer model in mice, we compare the potency of daily CR to that of periodic caloric cycling on FMD or an isocaloric standard laboratory chow against primary tumor growth and metastatic burden. Here, we report that daily CR provides greater protection against tumor growth and metastasis to the lung, which may be in part due to the unique immune signature observed with daily CR.

Date: 2021
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DOI: 10.1038/s41467-021-26431-4

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