Hedgehog artificial macrophage with atomic-catalytic centers to combat Drug-resistant bacteria

Yanping Long, Ling Li, Tao Xu, Xizheng Wu, Yun Gao, Jianbo Huang, Chao He, Tian Ma, Lang Ma, Chong Cheng () and Changsheng Zhao ()
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Yanping Long: Sichuan University
Ling Li: Sichuan University
Tao Xu: Sichuan University
Xizheng Wu: Sichuan University
Yun Gao: Sichuan University
Jianbo Huang: Sichuan University
Chao He: Sichuan University
Tian Ma: Sichuan University
Lang Ma: Sichuan University
Chong Cheng: Sichuan University
Changsheng Zhao: Sichuan University

Nature Communications, 2021, vol. 12, issue 1, 1-11

Abstract: Abstract Pathogenic drug-resistant bacteria represent a threat to human health, for instance, the methicillin-resistant Staphylococcus aureus (MRSA). There is an ever-growing need to develop non-antibiotic strategies to fight bacteria without triggering drug resistance. Here, we design a hedgehog artificial macrophage with atomic-catalytic centers to combat MRSA by mimicking the “capture and killing” process of macrophages. The experimental studies and theoretical calculations reveal that the synthesized materials can efficiently capture and kill MRSA by the hedgehog topography and substantial generation of •O2− and HClO with its Fe2N6O catalytic centers. The synthesized artificial macrophage exhibits a low minimal inhibition concentration (8 μg/mL Fe-Art M with H2O2 (100 μM)) to combat MRSA and rapidly promote the healing of bacteria-infected wounds on rabbit skin. We suggest that the application of this hedgehog artificial macrophage with “capture and killing” capability and high ROS-catalytic activity will open up a promising pathway to develop antibacterial materials for bionic and non-antibiotic disinfection strategies.

Date: 2021
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DOI: 10.1038/s41467-021-26456-9

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