Refining models of archaic admixture in Eurasia with ArchaicSeeker 2.0

Kai Yuan, Xumin Ni, Chang Liu, Yuwen Pan, Lian Deng, Rui Zhang, Yang Gao, Xueling Ge, Jiaojiao Liu, Xixian Ma, Haiyi Lou, Taoyang Wu and Shuhua Xu ()
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Kai Yuan: University of Chinese Academy of Sciences, Chinese Academy of Sciences
Xumin Ni: Beijing Jiaotong University
Chang Liu: University of Chinese Academy of Sciences, Chinese Academy of Sciences
Yuwen Pan: University of Chinese Academy of Sciences, Chinese Academy of Sciences
Lian Deng: Fudan University
Rui Zhang: University of Chinese Academy of Sciences, Chinese Academy of Sciences
Yang Gao: University of Chinese Academy of Sciences, Chinese Academy of Sciences
Xueling Ge: University of Chinese Academy of Sciences, Chinese Academy of Sciences
Jiaojiao Liu: Fudan University
Xixian Ma: University of Chinese Academy of Sciences, Chinese Academy of Sciences
Haiyi Lou: Fudan University
Taoyang Wu: University of East Anglia
Shuhua Xu: University of Chinese Academy of Sciences, Chinese Academy of Sciences

Nature Communications, 2021, vol. 12, issue 1, 1-15

Abstract: Abstract We developed a method, ArchaicSeeker 2.0, to identify introgressed hominin sequences and model multiple-wave admixture. The new method enabled us to discern two waves of introgression from both Denisovan-like and Neanderthal-like hominins in present-day Eurasian populations and an ancient Siberian individual. We estimated that an early Denisovan-like introgression occurred in Eurasia around 118.8–94.0 thousand years ago (kya). In contrast, we detected only one single episode of Denisovan-like admixture in indigenous peoples eastern to the Wallace-Line. Modeling ancient admixtures suggested an early dispersal of modern humans throughout Asia before the Toba volcanic super-eruption 74 kya, predating the initial peopling of Asia as proposed by the traditional Out-of-Africa model. Survived archaic sequences are involved in various phenotypes including immune and body mass (e.g., ZNF169), cardiovascular and lung function (e.g., HHAT), UV response and carbohydrate metabolism (e.g., HYAL1/HYAL2/HYAL3), while “archaic deserts” are enriched with genes associated with skin development and keratinization.

Date: 2021
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DOI: 10.1038/s41467-021-26503-5

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