Postpartum breast cancer has a distinct molecular profile that predicts poor outcomes

Sonali Jindal, Nathan D. Pennock, Duanchen Sun, Wesley Horton, Michelle K. Ozaki, Jayasri Narasimhan, Alexandra Q. Bartlett, Sheila Weinmann, Paul E. Goss, Virginia F. Borges, Zheng Xia and Pepper Schedin ()
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Sonali Jindal: Oregon Health & Science University
Nathan D. Pennock: Oregon Health & Science University
Duanchen Sun: Oregon Health & Science University
Wesley Horton: Oregon Health & Science University
Michelle K. Ozaki: Oregon Health & Science University
Jayasri Narasimhan: Oregon Health & Science University
Alexandra Q. Bartlett: Oregon Health & Science University
Sheila Weinmann: Kaiser Permanente Northwest
Paul E. Goss: Harvard University
Virginia F. Borges: University of Colorado Anschutz Medical Campus
Zheng Xia: Oregon Health & Science University
Pepper Schedin: Oregon Health & Science University

Nature Communications, 2021, vol. 12, issue 1, 1-15

Abstract: Abstract Young women’s breast cancer (YWBC) has poor prognosis and known interactions with parity. Women diagnosed within 5–10 years of childbirth, defined as postpartum breast cancer (PPBC), have poorer prognosis compared to age, stage, and biologic subtype-matched nulliparous patients. Genomic differences that explain this poor prognosis remain unknown. In this study, using RNA expression data from clinically matched estrogen receptor positive (ER+) cases (n = 16), we observe that ER+ YWBC can be differentiated based on a postpartum or nulliparous diagnosis. The gene expression signatures of PPBC are consistent with increased cell cycle, T-cell activation and reduced estrogen receptor and TP53 signaling. When applied to a large YWBC cohort, these signatures for ER+ PPBC associate with significantly reduced 15-year survival rates in high compared to low expressing cases. Cumulatively these results provide evidence that PPBC is a unique entity within YWBC with poor prognostic phenotypes.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26505-3

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DOI: 10.1038/s41467-021-26505-3

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