A live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters

Phanramphoei N. Frantz, Aleksandr Barinov, Claude Ruffié, Chantal Combredet, Valérie Najburg, Guilherme Dias de Melo, Florence Larrous, Lauriane Kergoat, Samaporn Teeravechyan, Anan Jongkaewwattana, Emmanuelle Billon-Denis, Jean-Nicolas Tournier, Matthieu Prot, Laurine Levillayer, Laurine Conquet, Xavier Montagutelli, Magali Tichit, David Hardy, Priyanka Fernandes, Hélène Strick-Marchand, James Di Santo, Etienne Simon-Lorière, Hervé Bourhy and Frédéric Tangy ()
Additional contact information
Phanramphoei N. Frantz: Université de Paris, Innovation Lab: Vaccines
Aleksandr Barinov: Université de Paris, Innovation Lab: Vaccines
Claude Ruffié: Université de Paris, Innovation Lab: Vaccines
Chantal Combredet: Université de Paris, Innovation Lab: Vaccines
Valérie Najburg: Université de Paris, Innovation Lab: Vaccines
Guilherme Dias de Melo: Université de Paris, Lyssavirus Epidemiology and Neuropathology Unit
Florence Larrous: Université de Paris, Lyssavirus Epidemiology and Neuropathology Unit
Lauriane Kergoat: Université de Paris, Lyssavirus Epidemiology and Neuropathology Unit
Samaporn Teeravechyan: Virology and Cell Technology Laboratory
Anan Jongkaewwattana: Virology and Cell Technology Laboratory
Emmanuelle Billon-Denis: Microbiology and infectious diseases department
Jean-Nicolas Tournier: Microbiology and infectious diseases department
Matthieu Prot: Université de Paris, Evolutionary Genomics of RNA viruses unit
Laurine Levillayer: Université de Paris, Evolutionary Genomics of RNA viruses unit
Laurine Conquet: Université de Paris, Laboratory of Mouse Genetics
Xavier Montagutelli: Université de Paris, Laboratory of Mouse Genetics
Magali Tichit: Université de Paris, Experimental Neuropathology unit
David Hardy: Université de Paris, Experimental Neuropathology unit
Priyanka Fernandes: Université de Paris, INSERM U1223, Innate Immunity unit
Hélène Strick-Marchand: Université de Paris, INSERM U1223, Innate Immunity unit
James Di Santo: Université de Paris, INSERM U1223, Innate Immunity unit
Etienne Simon-Lorière: Université de Paris, Evolutionary Genomics of RNA viruses unit
Hervé Bourhy: Université de Paris, Lyssavirus Epidemiology and Neuropathology Unit
Frédéric Tangy: Université de Paris, Innovation Lab: Vaccines

Nature Communications, 2021, vol. 12, issue 1, 1-17

Abstract: Abstract Several COVID-19 vaccines have now been deployed to tackle the SARS-CoV-2 pandemic, most of them based on messenger RNA or adenovirus vectors.The duration of protection afforded by these vaccines is unknown, as well as their capacity to protect from emerging new variants. To provide sufficient coverage for the world population, additional strategies need to be tested. The live pediatric measles vaccine (MV) is an attractive approach, given its extensive safety and efficacy history, along with its established large-scale manufacturing capacity. We develop an MV-based SARS-CoV-2 vaccine expressing the prefusion-stabilized, membrane-anchored full-length S antigen, which proves to be efficient at eliciting strong Th1-dominant T-cell responses and high neutralizing antibody titers. In both mouse and golden Syrian hamster models, these responses protect the animals from intranasal infectious challenge. Additionally, the elicited antibodies efficiently neutralize in vitro the three currently circulating variants of SARS-CoV-2.

Date: 2021
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DOI: 10.1038/s41467-021-26506-2

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