A giant NLR gene confers broad-spectrum resistance to Phytophthora sojae in soybean

Weidong Wang, Liyang Chen, Kevin Fengler, Joy Bolar, Victor Llaca, Xutong Wang, Chancelor B. Clark, Tomara J. Fleury, Jon Myrvold, David Oneal, Maria Magdalena Dyk, Ashley Hudson, Jesse Munkvold, Andy Baumgarten, Jeff Thompson, Guohong Cai, Oswald Crasta, Rajat Aggarwal () and Jianxin Ma ()
Additional contact information
Weidong Wang: Purdue University
Liyang Chen: Purdue University
Kevin Fengler: Corteva Agriscience™
Joy Bolar: Corteva Agriscience™
Victor Llaca: Corteva Agriscience™
Xutong Wang: Purdue University
Chancelor B. Clark: Purdue University
Tomara J. Fleury: Purdue University
Jon Myrvold: Corteva Agriscience™
David Oneal: Corteva Agriscience™
Maria Magdalena Dyk: Corteva Agriscience™
Ashley Hudson: Corteva Agriscience™
Jesse Munkvold: Corteva Agriscience™
Andy Baumgarten: Corteva Agriscience™
Jeff Thompson: Corteva Agriscience™
Guohong Cai: Purdue University
Oswald Crasta: Corteva Agriscience™
Rajat Aggarwal: Corteva Agriscience™
Jianxin Ma: Purdue University

Nature Communications, 2021, vol. 12, issue 1, 1-8

Abstract: Abstract Phytophthora root and stem rot caused by P. sojae is a destructive soybean soil-borne disease found worldwide. Discovery of genes conferring broad-spectrum resistance to the pathogen is a need to prevent the outbreak of the disease. Here, we show that soybean Rps11 is a 27.7-kb nucleotide-binding site-leucine-rich repeat (NBS-LRR or NLR) gene conferring broad-spectrum resistance to the pathogen. Rps11 is located in a genomic region harboring a cluster of large NLR genes of a single origin in soybean, and is derived from rounds of unequal recombination. Such events result in promoter fusion and LRR expansion that may contribute to the broad resistance spectrum. The NLR gene cluster exhibits drastic structural diversification among phylogenetically representative varieties, including gene copy number variation ranging from five to 23 copies, and absence of allelic copies of Rps11 in any of the non-Rps11-donor varieties examined, exemplifying innovative evolution of NLR genes and NLR gene clusters.

Date: 2021
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DOI: 10.1038/s41467-021-26554-8

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