Dynamic mechanochemical feedback between curved membranes and BAR protein self-organization

Anabel-Lise Le Roux (), Caterina Tozzi, Nikhil Walani, Xarxa Quiroga, Dobryna Zalvidea, Xavier Trepat, Margarita Staykova, Marino Arroyo () and Pere Roca-Cusachs ()
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Anabel-Lise Le Roux: Institute for Bioengineering of Catalonia (IBEC), the Barcelona Institute of Technology (BIST)
Caterina Tozzi: Universitat Politècnica de Catalunya (UPC)
Nikhil Walani: Universitat Politècnica de Catalunya (UPC)
Xarxa Quiroga: Institute for Bioengineering of Catalonia (IBEC), the Barcelona Institute of Technology (BIST)
Dobryna Zalvidea: Institute for Bioengineering of Catalonia (IBEC), the Barcelona Institute of Technology (BIST)
Xavier Trepat: Institute for Bioengineering of Catalonia (IBEC), the Barcelona Institute of Technology (BIST)
Margarita Staykova: University of Durham
Marino Arroyo: Institute for Bioengineering of Catalonia (IBEC), the Barcelona Institute of Technology (BIST)
Pere Roca-Cusachs: Institute for Bioengineering of Catalonia (IBEC), the Barcelona Institute of Technology (BIST)

Nature Communications, 2021, vol. 12, issue 1, 1-12

Abstract: Abstract In many physiological situations, BAR proteins reshape membranes with pre-existing curvature (templates), contributing to essential cellular processes. However, the mechanism and the biological implications of this reshaping process remain unclear. Here we show, both experimentally and through modelling, that BAR proteins reshape low curvature membrane templates through a mechanochemical phase transition. This phenomenon depends on initial template shape and involves the co-existence and progressive transition between distinct local states in terms of molecular organization (protein arrangement and density) and membrane shape (template size and spherical versus cylindrical curvature). Further, we demonstrate in cells that this phenomenon enables a mechanotransduction mode, in which cellular stretch leads to the mechanical formation of membrane templates, which are then reshaped into tubules by BAR proteins. Our results demonstrate the interplay between membrane mechanics and BAR protein molecular organization, integrating curvature sensing and generation in a comprehensive framework with implications for cell mechanical responses.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26591-3

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DOI: 10.1038/s41467-021-26591-3

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