Arabidopsis P4 ATPase-mediated cell detoxification confers resistance to Fusarium graminearum and Verticillium dahliae

Fanlong Wang, Xianbi Li, Yujie Li, Jing Han, Yang Chen, Jianyan Zeng, Mei Su, Jingxin Zhuo, Hui Ren, Haoru Liu, Lei Hou, Yanhua Fan, Xingying Yan, Shuiqing Song, Juan Zhao, Dan Jin, Mi Zhang and Yan Pei ()
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Fanlong Wang: Southwest University
Xianbi Li: Southwest University
Yujie Li: Southwest University
Jing Han: Southwest University
Yang Chen: Southwest University
Jianyan Zeng: Southwest University
Mei Su: Southwest University
Jingxin Zhuo: Southwest University
Hui Ren: Southwest University
Haoru Liu: Southwest University
Lei Hou: Southwest University
Yanhua Fan: Southwest University
Xingying Yan: Southwest University
Shuiqing Song: Southwest University
Juan Zhao: Southwest University
Dan Jin: Southwest University
Mi Zhang: Southwest University
Yan Pei: Southwest University

Nature Communications, 2021, vol. 12, issue 1, 1-16

Abstract: Abstract Many toxic secondary metabolites produced by phytopathogens can subvert host immunity, and some of them are recognized as pathogenicity factors. Fusarium head blight and Verticillium wilt are destructive plant diseases worldwide. Using toxins produced by the causal fungi Fusarium graminearum and Verticillium dahliae as screening agents, here we show that the Arabidopsis P4 ATPases AtALA1 and AtALA7 are responsible for cellular detoxification of mycotoxins. Through AtALA1-/AtALA7-mediated vesicle transport, toxins are sequestered in vacuoles for degradation. Overexpression of AtALA1 and AtALA7 significantly increases the resistance of transgenic plants to F. graminearum and V. dahliae, respectively. Notably, the concentration of deoxynivalenol, a mycotoxin harmful to the health of humans and animals, was decreased in transgenic Arabidopsis siliques and maize seeds. This vesicle-mediated cell detoxification process provides a strategy to increase plant resistance against different toxin-associated diseases and to reduce the mycotoxin contamination in food and feed.

Date: 2021
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DOI: 10.1038/s41467-021-26727-5

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