SET activation of nitroarenes by 2-azaallyl anions as a straightforward access to 2,5-dihydro-1,2,4-oxadiazoles

Dong Zou, Lishe Gan, Fan Yang, Huan Wang, Youge Pu, Jie Li () and Patrick J. Walsh ()
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Dong Zou: Zhejiang University City College
Lishe Gan: Wuyi University
Fan Yang: Zhejiang University City College
Huan Wang: Zhejiang University City College
Youge Pu: University of Pennsylvania
Jie Li: Zhejiang University City College
Patrick J. Walsh: University of Pennsylvania

Nature Communications, 2021, vol. 12, issue 1, 1-10

Abstract: Abstract The use of nitroarenes as amino sources in synthesis is challenging. Herein is reported an unusual, straightforward, and transition metal-free method for the net [3 + 2]-cycloaddition reaction of 2-azaallyl anions with nitroarenes. The products of this reaction are diverse 2,5-dihydro-1,2,4-oxadiazoles (>40 examples, up to 95% yield). This method does not require an external reductant to reduce nitroarenes, nor does it employ nitrosoarenes, which are often used in N–O cycloadditions. Instead, it is proposed that the 2-azaallyl anions, which behave as super electron donors (SEDs), deliver an electron to the nitroarene to generate a nitroarene radical anion. A downstream 2-azaallyl radical coupling with a newly formed nitrosoarene is followed by ring closure to afford the observed products. This proposed reaction pathway is supported by computational studies and experimental evidence. Overall, this method uses readily available materials, is green, and exhibits a broad scope.

Date: 2021
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DOI: 10.1038/s41467-021-26767-x

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