The parent-of-origin lncRNA MISSEN regulates rice endosperm development

Yan-Fei Zhou, Yu-Chan Zhang, Yu-Meng Sun, Yang Yu, Meng-Qi Lei, Yu-Wei Yang, Jian-Ping Lian, Yan-Zhao Feng, Zhi Zhang, Lu Yang, Rui-Rui He, Jia-Hui Huang, Yu Cheng, Yu-Wei Liu and Yue-Qin Chen ()
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Yan-Fei Zhou: Sun Yat-Sen University
Yu-Chan Zhang: Sun Yat-Sen University
Yu-Meng Sun: Sun Yat-Sen University
Yang Yu: Sun Yat-Sen University
Meng-Qi Lei: Sun Yat-Sen University
Yu-Wei Yang: Sun Yat-Sen University
Jian-Ping Lian: Sun Yat-Sen University
Yan-Zhao Feng: Sun Yat-Sen University
Zhi Zhang: Sun Yat-Sen University
Lu Yang: Sun Yat-Sen University
Rui-Rui He: Sun Yat-Sen University
Jia-Hui Huang: Sun Yat-Sen University
Yu Cheng: Sun Yat-Sen University
Yu-Wei Liu: Sun Yat-Sen University
Yue-Qin Chen: Sun Yat-Sen University

Nature Communications, 2021, vol. 12, issue 1, 1-14

Abstract: Abstract The cereal endosperm is a major factor determining seed size and shape. However, the molecular mechanisms of endosperm development are not fully understood. Long noncoding RNAs (lncRNAs) function in various biological processes. Here we show a lncRNA, MISSEN, that plays an essential role in early endosperm development in rice (Oryza sativa). MISSEN is a parent-of-origin lncRNA expressed in endosperm, and negatively regulates endosperm development, leading to a prominent dent and bulge in the seed. Mechanistically, MISSEN functions through hijacking a helicase family protein (HeFP) to regulate tubulin function during endosperm nucleus division and endosperm cellularization, resulting in abnormal cytoskeletal polymerization. Finally, we revealed that the expression of MISSEN is inhibited by histone H3 lysine 27 trimethylation (H3K27me3) modification after pollination. Therefore, MISSEN is the first lncRNA identified as a regulator in endosperm development, highlighting the potential applications in rice breeding.

Date: 2021
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DOI: 10.1038/s41467-021-26795-7

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