Aborting meiosis allows recombination in sterile diploid yeast hybrids

Simone Mozzachiodi, Lorenzo Tattini, Agnes Llored, Agurtzane Irizar, Neža Škofljanc, Melania D’Angiolo, Matteo De Chiara, Benjamin P. Barré, Jia-Xing Yue, Angela Lutazi, Sophie Loeillet, Raphaelle Laureau, Souhir Marsit, Simon Stenberg, Benoit Albaud, Karl Persson, Jean-Luc Legras, Sylvie Dequin, Jonas Warringer, Alain Nicolas and Gianni Liti ()
Additional contact information
Simone Mozzachiodi: Université Côte d’Azur, CNRS, INSERM, IRCAN
Lorenzo Tattini: Université Côte d’Azur, CNRS, INSERM, IRCAN
Agnes Llored: Université Côte d’Azur, CNRS, INSERM, IRCAN
Agurtzane Irizar: Université Côte d’Azur, CNRS, INSERM, IRCAN
Neža Škofljanc: Université Côte d’Azur, CNRS, INSERM, IRCAN
Melania D’Angiolo: Université Côte d’Azur, CNRS, INSERM, IRCAN
Matteo De Chiara: Université Côte d’Azur, CNRS, INSERM, IRCAN
Benjamin P. Barré: Université Côte d’Azur, CNRS, INSERM, IRCAN
Jia-Xing Yue: Université Côte d’Azur, CNRS, INSERM, IRCAN
Angela Lutazi: Université Côte d’Azur, CNRS, INSERM, IRCAN
Sophie Loeillet: Institut Curie, Centre de Recherche, CNRS-UMR3244, PSL Research University
Raphaelle Laureau: Institut Curie, Centre de Recherche, CNRS-UMR3244, PSL Research University
Souhir Marsit: Institut Curie, Centre de Recherche, CNRS-UMR3244, PSL Research University
Simon Stenberg: University of Gothenburg
Benoit Albaud: Institut Curie, ICGEX NGS Platform
Karl Persson: University of Gothenburg
Jean-Luc Legras: SPO, Université Montpellier, INRAE, Montpellier SupAgro
Sylvie Dequin: SPO, Université Montpellier, INRAE, Montpellier SupAgro
Jonas Warringer: University of Gothenburg
Alain Nicolas: Université Côte d’Azur, CNRS, INSERM, IRCAN
Gianni Liti: Université Côte d’Azur, CNRS, INSERM, IRCAN

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract Hybrids between diverged lineages contain novel genetic combinations but an impaired meiosis often makes them evolutionary dead ends. Here, we explore to what extent an aborted meiosis followed by a return-to-growth (RTG) promotes recombination across a panel of 20 Saccharomyces cerevisiae and S. paradoxus diploid hybrids with different genomic structures and levels of sterility. Genome analyses of 275 clones reveal that RTG promotes recombination and generates extensive regions of loss-of-heterozygosity in sterile hybrids with either a defective meiosis or a heavily rearranged karyotype, whereas RTG recombination is reduced by high sequence divergence between parental subgenomes. The RTG recombination preferentially arises in regions with low local heterozygosity and near meiotic recombination hotspots. The loss-of-heterozygosity has a profound impact on sexual and asexual fitness, and enables genetic mapping of phenotypic differences in sterile lineages where linkage analysis would fail. We propose that RTG gives sterile yeast hybrids access to a natural route for genome recombination and adaptation.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26883-8

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DOI: 10.1038/s41467-021-26883-8

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