Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damage
Mara Martín-Alonso (),
Sharif Iqbal,
Pia M. Vornewald,
Håvard T. Lindholm,
Mirjam J. Damen,
Fernando Martínez,
Sigrid Hoel,
Alberto Díez-Sánchez,
Maarten Altelaar,
Pekka Katajisto,
Alicia G. Arroyo and
Menno J. Oudhoff ()
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Mara Martín-Alonso: Norwegian University of Science and Technology
Sharif Iqbal: University of Helsinki
Pia M. Vornewald: Norwegian University of Science and Technology
Håvard T. Lindholm: Norwegian University of Science and Technology
Mirjam J. Damen: Utrecht University
Fernando Martínez: Bioinformatics Unit. Centro Nacional de Investigaciones Cardiovasculares (CNIC)
Sigrid Hoel: Norwegian University of Science and Technology
Alberto Díez-Sánchez: Norwegian University of Science and Technology
Maarten Altelaar: Utrecht University
Pekka Katajisto: University of Helsinki
Alicia G. Arroyo: Centro de Investigaciones Biológicas Margarita Salas (CIB-CSIC)
Menno J. Oudhoff: Norwegian University of Science and Technology
Nature Communications, 2021, vol. 12, issue 1, 1-17
Abstract:
Abstract Smooth muscle is an essential component of the intestine, both to maintain its structure and produce peristaltic and segmentation movements. However, very little is known about other putative roles that smooth muscle cells may have. Here, we show that smooth muscle cells may be the dominant suppliers of BMP antagonists, which are niche factors essential for intestinal stem cell maintenance. Furthermore, muscle-derived factors render epithelium reparative and fetal-like, which includes heightened YAP activity. Mechanistically, we find that the membrane-bound matrix metalloproteinase MMP17, which is exclusively expressed by smooth muscle cells, is required for intestinal epithelial repair after inflammation- or irradiation-induced injury. Furthermore, we propose that MMP17 affects intestinal epithelial reprogramming after damage indirectly by cleaving diffusible factor(s) such as the matricellular protein PERIOSTIN. Together, we identify an important signaling axis that establishes a role for smooth muscle cells as modulators of intestinal epithelial regeneration and the intestinal stem cell niche.
Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26904-6
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DOI: 10.1038/s41467-021-26904-6
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